Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

Murong Xu; Yang Yuan; Ye Wang; Yuanyang Mu; Huihui Xie; Yanzhong Li

doi:10.1016/j.tetlet.2021.152872

Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

Murong Xu
, Yang Yuan
, Ye Wang
, Yuanyang Mu
, Huihui Xie
, Yanzhong Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.

Original language	English
Article number	152872
Journal	Tetrahedron Letters
Volume	70
DOIs	https://doi.org/10.1016/j.tetlet.2021.152872
State	Published - 27 Apr 2021

Keywords

C[sbnd]H activation
Chelation-assisted
Cobalt
Regioselectivity
Spirosuccinimide

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10.1016/j.tetlet.2021.152872

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title = "Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides",

abstract = "A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.",

keywords = "C[sbnd]H activation, Chelation-assisted, Cobalt, Regioselectivity, Spirosuccinimide",

author = "Murong Xu and Yang Yuan and Ye Wang and Yuanyang Mu and Huihui Xie and Yanzhong Li",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = apr,

day = "27",

doi = "10.1016/j.tetlet.2021.152872",

language = "英语",

volume = "70",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides

T2 - Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

AU - Xu, Murong

AU - Yuan, Yang

AU - Wang, Ye

AU - Mu, Yuanyang

AU - Xie, Huihui

AU - Li, Yanzhong

PY - 2021/4/27

Y1 - 2021/4/27

N2 - A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.

AB - A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.

KW - C[sbnd]H activation

KW - Chelation-assisted

KW - Cobalt

KW - Regioselectivity

KW - Spirosuccinimide

UR - https://www.scopus.com/pages/publications/85103235531

U2 - 10.1016/j.tetlet.2021.152872

DO - 10.1016/j.tetlet.2021.152872

M3 - 文章

AN - SCOPUS:85103235531

SN - 0040-4039

VL - 70

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 152872

ER -

Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

Abstract

Keywords

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