Cis-clerodane diterpenoids from the liverwort Gottschelia schizopleura and their cytotoxic activity

Chun Mei Liu; Rui Liang Zhu; Run Hui Liu; Hui Liang Li; Lei Shan; Xi Ke Xu; Wei Dong Zhang

doi:10.1055/s-0029-1185837

Cis-clerodane diterpenoids from the liverwort Gottschelia schizopleura and their cytotoxic activity

Chun Mei Liu
, Rui Liang Zhu
, Run Hui Liu
, Hui Liang Li
, Lei Shan
, Xi Ke Xu
, Wei Dong Zhang^*

^*Corresponding author for this work

School of Life Sciences

Naval Medical University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two new and three previously known cis-clerodane diterpenoids were isolated from the wild liverwort Gottschelia schizopleura (Jungermanniales, Jungermanniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D and 2D NMR data. The cytotoxic activities of compounds 15 were evaluated against liver hepatoblastoma (HEPG2), lung carcinoma (A549), breast ductal carcinoma (MDAMB435), and colon adenocarcinoma (LOVO) cell lines. Compound 1 showed moderate inhibition against MDAMB435 and LOVO cells.

Original language	English
Pages (from-to)	1597-1601
Number of pages	5
Journal	Planta Medica
Volume	75
Issue number	15
DOIs	https://doi.org/10.1055/s-0029-1185837
State	Published - 2009

Keywords

Cis clerodane diterpenoids
Cytotoxic activity
Gottschelia schizopleura
Jungermanniaceae

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10.1055/s-0029-1185837

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title = "Cis-clerodane diterpenoids from the liverwort Gottschelia schizopleura and their cytotoxic activity",

abstract = "Two new and three previously known cis-clerodane diterpenoids were isolated from the wild liverwort Gottschelia schizopleura (Jungermanniales, Jungermanniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D and 2D NMR data. The cytotoxic activities of compounds 15 were evaluated against liver hepatoblastoma (HEPG2), lung carcinoma (A549), breast ductal carcinoma (MDAMB435), and colon adenocarcinoma (LOVO) cell lines. Compound 1 showed moderate inhibition against MDAMB435 and LOVO cells.",

keywords = "Cis clerodane diterpenoids, Cytotoxic activity, Gottschelia schizopleura, Jungermanniaceae",

author = "Liu, \{Chun Mei\} and Zhu, \{Rui Liang\} and Liu, \{Run Hui\} and Li, \{Hui Liang\} and Lei Shan and Xu, \{Xi Ke\} and Zhang, \{Wei Dong\}",

year = "2009",

doi = "10.1055/s-0029-1185837",

language = "英语",

volume = "75",

pages = "1597--1601",

journal = "Planta Medica",

issn = "0032-0943",

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TY - JOUR

T1 - Cis-clerodane diterpenoids from the liverwort Gottschelia schizopleura and their cytotoxic activity

AU - Liu, Chun Mei

AU - Zhu, Rui Liang

AU - Liu, Run Hui

AU - Li, Hui Liang

AU - Shan, Lei

AU - Xu, Xi Ke

AU - Zhang, Wei Dong

PY - 2009

Y1 - 2009

N2 - Two new and three previously known cis-clerodane diterpenoids were isolated from the wild liverwort Gottschelia schizopleura (Jungermanniales, Jungermanniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D and 2D NMR data. The cytotoxic activities of compounds 15 were evaluated against liver hepatoblastoma (HEPG2), lung carcinoma (A549), breast ductal carcinoma (MDAMB435), and colon adenocarcinoma (LOVO) cell lines. Compound 1 showed moderate inhibition against MDAMB435 and LOVO cells.

AB - Two new and three previously known cis-clerodane diterpenoids were isolated from the wild liverwort Gottschelia schizopleura (Jungermanniales, Jungermanniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D and 2D NMR data. The cytotoxic activities of compounds 15 were evaluated against liver hepatoblastoma (HEPG2), lung carcinoma (A549), breast ductal carcinoma (MDAMB435), and colon adenocarcinoma (LOVO) cell lines. Compound 1 showed moderate inhibition against MDAMB435 and LOVO cells.

KW - Cis clerodane diterpenoids

KW - Cytotoxic activity

KW - Gottschelia schizopleura

KW - Jungermanniaceae

UR - https://www.scopus.com/pages/publications/73949111013

U2 - 10.1055/s-0029-1185837

DO - 10.1055/s-0029-1185837

M3 - 文章

C2 - 19579183

AN - SCOPUS:73949111013

SN - 0032-0943

VL - 75

SP - 1597

EP - 1601

JO - Planta Medica

JF - Planta Medica

IS - 15

ER -

Cis-clerodane diterpenoids from the liverwort Gottschelia schizopleura and their cytotoxic activity

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Keywords

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