Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region

Xiaoyun Guo; Yingmei Fu; Yifeng Xu; Shimin Weng; Dengtang Liu; Donghong Cui; Shunying Yu; Xiaohua Liu; Kaida Jiang; Yi Dong

doi:10.1016/j.neulet.2012.06.075

Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region

Xiaoyun Guo, Yingmei Fu, Yifeng Xu, Shimin Weng, Dengtang Liu, Donghong Cui, Shunying Yu, Xiaohua Liu, Kaida Jiang, Yi Dong

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Inflammation contributes to the pathophysiology of depression. Chemokine-like receptor-1 (CMKLR1) plays an important role both in the development of inflammation and in the mechanism of antidepressant effect of Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), ecosapeatanolicacid (EPA). The present study was to investigate the modification of CMKLR1 in chronic restraint stress (CRS) rats. CMKLR1 was examined in different brain region from CRS rats by using western blot and quantitative real-time PCR. The CMKLR1 expression in the hippocampus, prefrontal cortex and cerebellum was determined on 3, 7, 10 and 21 days of repeated restraint stress and was compared to controls. The results showed that the protein and mRNA level of CMKLR1 in the prefrontal cortex and hippocampus were significantly increased on day 3 and then decreased on day 7, 10 and 21 in the CRS rats. The protein and mRNA level of CMKLR1 in cerebellum was similar to that of control group throughout the whole experiment. Changed expression of brain CMKLR1 is suggested to be involved in the mechanism of depression.

Original language	English
Pages (from-to)	25-29
Number of pages	5
Journal	Neuroscience Letters
Volume	524
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2012.06.075
State	Published - 22 Aug 2012
Externally published	Yes

Keywords

CMKLR1
Chronic restraint stress
Depression
Hippocampus
Prefrontal cortex

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10.1016/j.neulet.2012.06.075

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@article{dde28524616c4f18b68b0f38f4a69ac7,

title = "Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region",

abstract = "Inflammation contributes to the pathophysiology of depression. Chemokine-like receptor-1 (CMKLR1) plays an important role both in the development of inflammation and in the mechanism of antidepressant effect of Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), ecosapeatanolicacid (EPA). The present study was to investigate the modification of CMKLR1 in chronic restraint stress (CRS) rats. CMKLR1 was examined in different brain region from CRS rats by using western blot and quantitative real-time PCR. The CMKLR1 expression in the hippocampus, prefrontal cortex and cerebellum was determined on 3, 7, 10 and 21 days of repeated restraint stress and was compared to controls. The results showed that the protein and mRNA level of CMKLR1 in the prefrontal cortex and hippocampus were significantly increased on day 3 and then decreased on day 7, 10 and 21 in the CRS rats. The protein and mRNA level of CMKLR1 in cerebellum was similar to that of control group throughout the whole experiment. Changed expression of brain CMKLR1 is suggested to be involved in the mechanism of depression.",

keywords = "CMKLR1, Chronic restraint stress, Depression, Hippocampus, Prefrontal cortex",

author = "Xiaoyun Guo and Yingmei Fu and Yifeng Xu and Shimin Weng and Dengtang Liu and Donghong Cui and Shunying Yu and Xiaohua Liu and Kaida Jiang and Yi Dong",

year = "2012",

month = aug,

day = "22",

doi = "10.1016/j.neulet.2012.06.075",

language = "英语",

volume = "524",

pages = "25--29",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region

AU - Guo, Xiaoyun

AU - Fu, Yingmei

AU - Xu, Yifeng

AU - Weng, Shimin

AU - Liu, Dengtang

AU - Cui, Donghong

AU - Yu, Shunying

AU - Liu, Xiaohua

AU - Jiang, Kaida

AU - Dong, Yi

PY - 2012/8/22

Y1 - 2012/8/22

N2 - Inflammation contributes to the pathophysiology of depression. Chemokine-like receptor-1 (CMKLR1) plays an important role both in the development of inflammation and in the mechanism of antidepressant effect of Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), ecosapeatanolicacid (EPA). The present study was to investigate the modification of CMKLR1 in chronic restraint stress (CRS) rats. CMKLR1 was examined in different brain region from CRS rats by using western blot and quantitative real-time PCR. The CMKLR1 expression in the hippocampus, prefrontal cortex and cerebellum was determined on 3, 7, 10 and 21 days of repeated restraint stress and was compared to controls. The results showed that the protein and mRNA level of CMKLR1 in the prefrontal cortex and hippocampus were significantly increased on day 3 and then decreased on day 7, 10 and 21 in the CRS rats. The protein and mRNA level of CMKLR1 in cerebellum was similar to that of control group throughout the whole experiment. Changed expression of brain CMKLR1 is suggested to be involved in the mechanism of depression.

AB - Inflammation contributes to the pathophysiology of depression. Chemokine-like receptor-1 (CMKLR1) plays an important role both in the development of inflammation and in the mechanism of antidepressant effect of Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), ecosapeatanolicacid (EPA). The present study was to investigate the modification of CMKLR1 in chronic restraint stress (CRS) rats. CMKLR1 was examined in different brain region from CRS rats by using western blot and quantitative real-time PCR. The CMKLR1 expression in the hippocampus, prefrontal cortex and cerebellum was determined on 3, 7, 10 and 21 days of repeated restraint stress and was compared to controls. The results showed that the protein and mRNA level of CMKLR1 in the prefrontal cortex and hippocampus were significantly increased on day 3 and then decreased on day 7, 10 and 21 in the CRS rats. The protein and mRNA level of CMKLR1 in cerebellum was similar to that of control group throughout the whole experiment. Changed expression of brain CMKLR1 is suggested to be involved in the mechanism of depression.

KW - CMKLR1

KW - Chronic restraint stress

KW - Depression

KW - Hippocampus

KW - Prefrontal cortex

UR - https://www.scopus.com/pages/publications/84864628532

U2 - 10.1016/j.neulet.2012.06.075

DO - 10.1016/j.neulet.2012.06.075

M3 - 文章

C2 - 22796467

AN - SCOPUS:84864628532

SN - 0304-3940

VL - 524

SP - 25

EP - 29

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region

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Keywords

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