TY - JOUR
T1 - Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
AU - Fan, Mingxue
AU - Li, Minghao
AU - Gao, Lipeng
AU - Geng, Sicong
AU - Wang, Jing
AU - Wang, Yiting
AU - Yan, Zhiqiang
AU - Yu, Lei
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/8/29
Y1 - 2017/8/29
N2 - Currently, conventional therapies for acute myeloid leukemia (AML) have high failure and relapse rates. Thus, developing new strategies is crucial for improving the treatment of AML. With the clinical success of anti-CD19 chimeric antigen receptor (CAR) T cell therapies against B-lineage malignancies, many studies have attempted to translate the success of CAR T cell therapy to other malignancies, including AML. This review summarizes the current advances in CAR T cell therapy against AML, including preclinical studies and clinical trials, and discusses the potential AML-associated surface markers that could be used for further CAR technology. Finally, we describe strategies that might address the current issues of employing CAR T cell therapy in AML.
AB - Currently, conventional therapies for acute myeloid leukemia (AML) have high failure and relapse rates. Thus, developing new strategies is crucial for improving the treatment of AML. With the clinical success of anti-CD19 chimeric antigen receptor (CAR) T cell therapies against B-lineage malignancies, many studies have attempted to translate the success of CAR T cell therapy to other malignancies, including AML. This review summarizes the current advances in CAR T cell therapy against AML, including preclinical studies and clinical trials, and discusses the potential AML-associated surface markers that could be used for further CAR technology. Finally, we describe strategies that might address the current issues of employing CAR T cell therapy in AML.
KW - Acute myeloid leukemia
KW - Chimeric antigen receptors
KW - Immunotherapy
UR - https://www.scopus.com/pages/publications/85028539787
U2 - 10.1186/s13045-017-0519-7
DO - 10.1186/s13045-017-0519-7
M3 - 文献综述
C2 - 28851445
AN - SCOPUS:85028539787
SN - 1756-8722
VL - 10
JO - Journal of Hematology and Oncology
JF - Journal of Hematology and Oncology
IS - 1
M1 - 151
ER -
