Chemoenzymatic synthesis of macrocyclic polyamines

Wei Lu; Charles J. Sih

doi:10.1016/S0040-4039(99)00954-5

Chemoenzymatic synthesis of macrocyclic polyamines

Wei Lu
, Charles J. Sih^*

^*Corresponding author for this work

University of Wisconsin-Madison

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

(±)-Azamacrolides were synthesized via lipase-catalyzed intramolecular cyclization of (±)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small number of hydroxy-azaesters using this biocatalytic approach.

Original language	English
Pages (from-to)	4965-4968
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	27
DOIs	https://doi.org/10.1016/S0040-4039(99)00954-5
State	Published - 2 Jul 1999
Externally published	Yes

Access to Document

10.1016/S0040-4039(99)00954-5

Cite this

@article{f1fdf9e2439c4009a81f1aa0d8498d22,

title = "Chemoenzymatic synthesis of macrocyclic polyamines",

abstract = "(±)-Azamacrolides were synthesized via lipase-catalyzed intramolecular cyclization of (±)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small number of hydroxy-azaesters using this biocatalytic approach.",

author = "Wei Lu and Sih, \{Charles J.\}",

year = "1999",

month = jul,

day = "2",

doi = "10.1016/S0040-4039(99)00954-5",

language = "英语",

volume = "40",

pages = "4965--4968",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "27",

}

TY - JOUR

T1 - Chemoenzymatic synthesis of macrocyclic polyamines

AU - Lu, Wei

AU - Sih, Charles J.

PY - 1999/7/2

Y1 - 1999/7/2

N2 - (±)-Azamacrolides were synthesized via lipase-catalyzed intramolecular cyclization of (±)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small number of hydroxy-azaesters using this biocatalytic approach.

AB - (±)-Azamacrolides were synthesized via lipase-catalyzed intramolecular cyclization of (±)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small number of hydroxy-azaesters using this biocatalytic approach.

UR - https://www.scopus.com/pages/publications/0033516518

U2 - 10.1016/S0040-4039(99)00954-5

DO - 10.1016/S0040-4039(99)00954-5

M3 - 文章

AN - SCOPUS:0033516518

SN - 0040-4039

VL - 40

SP - 4965

EP - 4968

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 27

ER -

Chemoenzymatic synthesis of macrocyclic polyamines

Abstract

Access to Document

Other files and links

Fingerprint

Cite this