Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Zhongmin Tang; Yanyan Liu; Mingyuan He; Wenbo Bu

doi:10.1002/anie.201805664

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Zhongmin Tang
, Yanyan Liu
, Mingyuan He
, Wenbo Bu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Review article › peer-review

1813 Scopus citations

Abstract

Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ( ^. OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of ^. OH generated. Notably, various strategies based on the Fenton reaction have been employed to enhance ^. OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area.

Original language	English
Pages (from-to)	946-956
Number of pages	11
Journal	Angewandte Chemie - International Edition
Volume	58
Issue number	4
DOIs	https://doi.org/10.1002/anie.201805664
State	Published - 21 Jan 2019

Keywords

Fenton reaction
chemodynamic therapy
external energy fields
nanomaterials selection
reaction environment

Access to Document

10.1002/anie.201805664

Cite this

@article{0597fa0fae4e4e1fa21b7ace3f9ee45c,

title = "Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions",

abstract = " Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ( . OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of . OH generated. Notably, various strategies based on the Fenton reaction have been employed to enhance . OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area.",

keywords = "Fenton reaction, chemodynamic therapy, external energy fields, nanomaterials selection, reaction environment",

author = "Zhongmin Tang and Yanyan Liu and Mingyuan He and Wenbo Bu",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = jan,

day = "21",

doi = "10.1002/anie.201805664",

language = "英语",

volume = "58",

pages = "946--956",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "4",

}

TY - JOUR

T1 - Chemodynamic Therapy

T2 - Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

AU - Tang, Zhongmin

AU - Liu, Yanyan

AU - He, Mingyuan

AU - Bu, Wenbo

PY - 2019/1/21

Y1 - 2019/1/21

N2 - Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ( . OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of . OH generated. Notably, various strategies based on the Fenton reaction have been employed to enhance . OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area.

AB - Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ( . OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of . OH generated. Notably, various strategies based on the Fenton reaction have been employed to enhance . OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area.

KW - Fenton reaction

KW - chemodynamic therapy

KW - external energy fields

KW - nanomaterials selection

KW - reaction environment

UR - https://www.scopus.com/pages/publications/85055714389

U2 - 10.1002/anie.201805664

DO - 10.1002/anie.201805664

M3 - 文献综述

C2 - 30048028

AN - SCOPUS:85055714389

SN - 1433-7851

VL - 58

SP - 946

EP - 956

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 4

ER -

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this