Abstract
Induced pluripotent stem cell (iPSC) technology represents a breakthrough and offers new perspectives in terms of generating functional cardiomyocytes. Different combinations of chemical compounds that can replace exogenous factors and enhance reprogramming efficiency have been identified. A profound understanding of heart development has laid the foundation for heart regeneration. Recent advances in heart regeneration indicate that cardiomyocyte regeneration occurs primarily through division of differentiating cardiac cells. High-throughput and high-content small-molecule screening studies, particularly in zebrafish, provide insights into heart development and regeneration and shall be the new frontiers in translating cardiovascular research.
| Original language | English |
|---|---|
| Title of host publication | Chemical Biology in Regenerative Medicine |
| Subtitle of host publication | Bridging Stem Cells and Future Therapies |
| Publisher | wiley |
| Pages | 35-47 |
| Number of pages | 13 |
| ISBN (Electronic) | 9781118695746 |
| ISBN (Print) | 9781118349595 |
| DOIs | |
| State | Published - 4 Jul 2014 |
| Externally published | Yes |
Keywords
- Cardiomyocyte
- IPSCs
- Regeneration
- Small molecule
- Transdifferentiation
- Zebrafish