Abstract
Redox signal transduction, especially the oxidative modification of proein thiols, correlates with many diseases and becomes an expanding research area. However, there was rare method for quick and specific detection of protein thiols and their oxidative modification in living cells. In this article, we review the current chemical strategies for the detection and quantification of protein thiols and related cysteine oxidation. We also look into the future of the development of fluorescent probes for protein thiols and their potential application in the research of reactive cysteine proteomes and early detection of redox-related diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 280-290 |
| Number of pages | 11 |
| Journal | Yaoxue Xuebao |
| Volume | 47 |
| Issue number | 3 |
| State | Published - 12 Mar 2012 |
| Externally published | Yes |
Keywords
- Detection
- Fluorescent probe
- Oxidative modification
- Protein thiol
- Redox