Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent

Meicheng Yang; Lipeng Gao; Kai Liu; Chunhua Luo; Yiting Wang; Lei Yu; Hui Peng; Wen Zhang

doi:10.1016/j.talanta.2014.08.042

Characterization of Fe₃O₄/SiO₂/Gd₂O(CO₃)₂ core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent

Meicheng Yang, Lipeng Gao, Kai Liu, Chunhua Luo, Yiting Wang, Lei Yu, Hui Peng, Wen Zhang

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Core/shell/shell structured Fe₃O₄/SiO₂/Gd₂O(CO₃)₂ nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO₂ layer, the magnetic coupling between Gd₂O(CO₃)₂ and Fe₃O₄ could be modulated by the thickness of SiO₂ layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd³⁺ enhances the transverse relaxivity of Fe₃O₄ possibly because of the magnetic coupling between Gd³⁺ and Fe₃O₄. The Fe₃O₄/SiO₂/Gd₂O(CO₃)₂ nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications.

Original language	English
Pages (from-to)	661-665
Number of pages	5
Journal	Talanta
Volume	131
DOIs	https://doi.org/10.1016/j.talanta.2014.08.042
State	Published - Jan 2015

Keywords

Contrast agents
FeO/SiO/GdO(CO)
Magnetic resonance imaging
Nanoparticles

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10.1016/j.talanta.2014.08.042

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title = "Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent",

abstract = "Core/shell/shell structured Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)2 and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd3+ enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd3+ and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications.",

keywords = "Contrast agents, FeO/SiO/GdO(CO), Magnetic resonance imaging, Nanoparticles",

author = "Meicheng Yang and Lipeng Gao and Kai Liu and Chunhua Luo and Yiting Wang and Lei Yu and Hui Peng and Wen Zhang",

year = "2015",

month = jan,

doi = "10.1016/j.talanta.2014.08.042",

language = "英语",

volume = "131",

pages = "661--665",

journal = "Talanta",

issn = "0039-9140",

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T1 - Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent

AU - Yang, Meicheng

AU - Gao, Lipeng

AU - Liu, Kai

AU - Luo, Chunhua

AU - Wang, Yiting

AU - Yu, Lei

AU - Peng, Hui

AU - Zhang, Wen

PY - 2015/1

Y1 - 2015/1

N2 - Core/shell/shell structured Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)2 and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd3+ enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd3+ and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications.

AB - Core/shell/shell structured Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)2 and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd3+ enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd3+ and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications.

KW - Contrast agents

KW - FeO/SiO/GdO(CO)

KW - Magnetic resonance imaging

KW - Nanoparticles

UR - https://www.scopus.com/pages/publications/84908405882

U2 - 10.1016/j.talanta.2014.08.042

DO - 10.1016/j.talanta.2014.08.042

M3 - 文章

C2 - 25281156

AN - SCOPUS:84908405882

SN - 0039-9140

VL - 131

SP - 661

EP - 665

JO - Talanta

JF - Talanta

ER -

Characterization of Fe₃O₄/SiO₂/Gd₂O(CO₃)₂ core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent

Abstract

Keywords

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