Cellulose-reinforced poly(Ionic Liquids) composite hydrogel for infected wounds therapy and real-time reliable bioelectronic

With the increasing utilization of therapeutic materials in wound care and skin bioelectronics, there is growing requirements for multifunctional hydrogels for personal therapy and health management. However, the limited functionality, mechanical incompatibility, and impracticality of traditional dressings and skin bioelectronics greatly restrict their widespread use in clinical settings. Herein, we fabricate a cellulose nanofibers (CNFs)-reinforced poly(Ionic Liquids) (PILs) composite hydrogel (PAC_xV_y) which can be used as infected wound therapy and real-time reliable bioelectronic. The hydrogel showed an orderly interconnected cellular architecture with excellent stretchability, outstanding elasticity and low hysteresis. As a wound dressing, the hydrogel could provide the adhesion to seal wounds, biocompatibility and outstanding antibacterial activity, enabling the wound dressing to effectively inhibit bacterial growth and accelerate infected wound healing. ILs enables the hydrogel to have high conductivity, outstanding sensing performance and impressive temperature response. Therefore, the hydrogel may also work as novel flexible bioelectronics, which could accurately capture motion signals ranging from large strain to minute physiological signal, such as body movement, heart rate, pulse, and body temperature. Notably, a dual-channel remote clinical alarm system was fabricated by combining the hydrogel with tailor-made single-chip to wireless real-time monitoring of finger joint movement and temperature changes, which could establish a communication channel between patient and wounded and provide effective medical intervention timely. This line of research work sheds light on the hydrogel has significant implications for improving personal therapy and health management.