Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

Mingshu Xiao; Li Li; Hao Pei

doi:10.1007/978-1-0716-4394-5_9

Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

Mingshu Xiao
, Li Li
, Hao Pei^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Developing simple, yet effective strategies to program cell–cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	117-130
Number of pages	14
DOIs	https://doi.org/10.1007/978-1-0716-4394-5_9
State	Published - 2025

Publication series

Name	Methods in Molecular Biology
Volume	2901
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cell surface engineering
Cell-based immunotherapy
Cell–cell interactions
DNA circuit
Framework nucleic acid

Access to Document

10.1007/978-1-0716-4394-5_9

Cite this

@inbook{522f35396ec447a487c0d9e1a83b84f6,

title = "Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions",

abstract = "Developing simple, yet effective strategies to program cell{\textendash}cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.",

keywords = "Cell surface engineering, Cell-based immunotherapy, Cell{\textendash}cell interactions, DNA circuit, Framework nucleic acid",

author = "Mingshu Xiao and Li Li and Hao Pei",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025.",

year = "2025",

doi = "10.1007/978-1-0716-4394-5\_9",

language = "英语",

series = "Methods in Molecular Biology",

publisher = "Humana Press Inc.",

pages = "117--130",

booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

AU - Xiao, Mingshu

AU - Li, Li

AU - Pei, Hao

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025.

PY - 2025

Y1 - 2025

N2 - Developing simple, yet effective strategies to program cell–cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.

AB - Developing simple, yet effective strategies to program cell–cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.

KW - Cell surface engineering

KW - Cell-based immunotherapy

KW - Cell–cell interactions

KW - DNA circuit

KW - Framework nucleic acid

UR - https://www.scopus.com/pages/publications/105002823656

U2 - 10.1007/978-1-0716-4394-5_9

DO - 10.1007/978-1-0716-4394-5_9

M3 - 章节

C2 - 40175871

AN - SCOPUS:105002823656

T3 - Methods in Molecular Biology

SP - 117

EP - 130

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

Abstract

Publication series

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this