Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H                         2                         S in living cells and zebrafish

Fangfang Wang; Cuiling Zhang; Xuetong Qu; Shasha Cheng; Yuezhong Xian

doi:10.1016/j.bios.2018.10.056

Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H ₂ S in living cells and zebrafish

Fangfang Wang
, Cuiling Zhang^*
, Xuetong Qu
, Shasha Cheng
, Yuezhong Xian

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Elevated hydrogen sulfide (H ₂ S) level is closely associated with various diseases. So the sensing of H ₂ S is noteworthy for divulging its role in diagnosing these diseases. Herein, we proposed poly(acrylic acid)-modified upconversion nanoparticles assembled with cationic near-infrared cyanine chromophores (Cy7-Cl) as the nanoprobe (Cy7-UCNPs) for monitoring H ₂ S based on thiolation reactions. The presence of H ₂ S resulted into about five-fold enhancement in the luminescence intensity of Cy7-UCNPs and the nanoprobe showed a good linearity (R ² =0.9952) over the range of 1.0 − 90 μM. Furthermore, Cy7-UCNPs were successfully employed in sensing and imaging of exogenous and endogenous H ₂ S in live cells and zebrafish. The system shows great potential in the field of nanobiomedicine because of the many excellent properties including high sensitivity, good selectivity, and low cytotoxicity.

Original language	English
Pages (from-to)	96-101
Number of pages	6
Journal	Biosensors and Bioelectronics
Volume	126
DOIs	https://doi.org/10.1016/j.bios.2018.10.056
State	Published - 1 Feb 2019

Keywords

Bioimaging
Chromophore
Hydrogen sulfide (H S)
Turn-on fluorescent probe
Upconversion nanoparticles

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10.1016/j.bios.2018.10.056

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@article{832255c8e0484a28858eec4dd87f0511,

title = " Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H 2 S in living cells and zebrafish ",

abstract = " Elevated hydrogen sulfide (H 2 S) level is closely associated with various diseases. So the sensing of H 2 S is noteworthy for divulging its role in diagnosing these diseases. Herein, we proposed poly(acrylic acid)-modified upconversion nanoparticles assembled with cationic near-infrared cyanine chromophores (Cy7-Cl) as the nanoprobe (Cy7-UCNPs) for monitoring H 2 S based on thiolation reactions. The presence of H 2 S resulted into about five-fold enhancement in the luminescence intensity of Cy7-UCNPs and the nanoprobe showed a good linearity (R 2 =0.9952) over the range of 1.0 − 90 μM. Furthermore, Cy7-UCNPs were successfully employed in sensing and imaging of exogenous and endogenous H 2 S in live cells and zebrafish. The system shows great potential in the field of nanobiomedicine because of the many excellent properties including high sensitivity, good selectivity, and low cytotoxicity.",

keywords = "Bioimaging, Chromophore, Hydrogen sulfide (H S), Turn-on fluorescent probe, Upconversion nanoparticles",

author = "Fangfang Wang and Cuiling Zhang and Xuetong Qu and Shasha Cheng and Yuezhong Xian",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2019",

month = feb,

day = "1",

doi = "10.1016/j.bios.2018.10.056",

language = "英语",

volume = "126",

pages = "96--101",

journal = "Biosensors and Bioelectronics",

issn = "0956-5663",

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Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H ₂ S in living cells and zebrafish . / Wang, Fangfang; Zhang, Cuiling; Qu, Xuetong et al.
In: Biosensors and Bioelectronics, Vol. 126, 01.02.2019, p. 96-101.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H 2 S in living cells and zebrafish

AU - Wang, Fangfang

AU - Zhang, Cuiling

AU - Qu, Xuetong

AU - Cheng, Shasha

AU - Xian, Yuezhong

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Elevated hydrogen sulfide (H 2 S) level is closely associated with various diseases. So the sensing of H 2 S is noteworthy for divulging its role in diagnosing these diseases. Herein, we proposed poly(acrylic acid)-modified upconversion nanoparticles assembled with cationic near-infrared cyanine chromophores (Cy7-Cl) as the nanoprobe (Cy7-UCNPs) for monitoring H 2 S based on thiolation reactions. The presence of H 2 S resulted into about five-fold enhancement in the luminescence intensity of Cy7-UCNPs and the nanoprobe showed a good linearity (R 2 =0.9952) over the range of 1.0 − 90 μM. Furthermore, Cy7-UCNPs were successfully employed in sensing and imaging of exogenous and endogenous H 2 S in live cells and zebrafish. The system shows great potential in the field of nanobiomedicine because of the many excellent properties including high sensitivity, good selectivity, and low cytotoxicity.

AB - Elevated hydrogen sulfide (H 2 S) level is closely associated with various diseases. So the sensing of H 2 S is noteworthy for divulging its role in diagnosing these diseases. Herein, we proposed poly(acrylic acid)-modified upconversion nanoparticles assembled with cationic near-infrared cyanine chromophores (Cy7-Cl) as the nanoprobe (Cy7-UCNPs) for monitoring H 2 S based on thiolation reactions. The presence of H 2 S resulted into about five-fold enhancement in the luminescence intensity of Cy7-UCNPs and the nanoprobe showed a good linearity (R 2 =0.9952) over the range of 1.0 − 90 μM. Furthermore, Cy7-UCNPs were successfully employed in sensing and imaging of exogenous and endogenous H 2 S in live cells and zebrafish. The system shows great potential in the field of nanobiomedicine because of the many excellent properties including high sensitivity, good selectivity, and low cytotoxicity.

KW - Bioimaging

KW - Chromophore

KW - Hydrogen sulfide (H S)

KW - Turn-on fluorescent probe

KW - Upconversion nanoparticles

UR - https://www.scopus.com/pages/publications/85055891029

U2 - 10.1016/j.bios.2018.10.056

DO - 10.1016/j.bios.2018.10.056

M3 - 文章

C2 - 30396023

AN - SCOPUS:85055891029

SN - 0956-5663

VL - 126

SP - 96

EP - 101

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

ER -

Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H ₂ S in living cells and zebrafish

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Keywords

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