Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

Peng Wei Xu; Jin Sheng Yu; Chen Chen; Zhong Yan Cao; Feng Zhou; Jian Zhou

doi:10.1021/acscatal.8b03694

Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

Peng Wei Xu, Jin Sheng Yu, Chen Chen, Zhong Yan Cao, Feng Zhou, Jian Zhou

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

281 Scopus citations

Abstract

The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary carbon stereocenter is currently of great interest because such privileged 3D structures are widely present in natural products that exhibit a broad spectrum of biological and pharmacological activities. This review summarizes the advances based on six major synthetic strategies and showcases the reaction mechanisms in detail. The advantages and limitations of each synthetic strategy are presented, and the remaining synthetic opportunities are outlined.

Original language	English
Pages (from-to)	1820-1882
Number of pages	63
Journal	ACS Catalysis
Volume	9
Issue number	3
DOIs	https://doi.org/10.1021/acscatal.8b03694
State	Published - 1 Mar 2019

Keywords

catalytic enantioselective
metal catalysis
organocatalysis
reaction mechanism
spiro quaternary carbon stereocenters

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10.1021/acscatal.8b03694

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abstract = "The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary carbon stereocenter is currently of great interest because such privileged 3D structures are widely present in natural products that exhibit a broad spectrum of biological and pharmacological activities. This review summarizes the advances based on six major synthetic strategies and showcases the reaction mechanisms in detail. The advantages and limitations of each synthetic strategy are presented, and the remaining synthetic opportunities are outlined.",

keywords = "catalytic enantioselective, metal catalysis, organocatalysis, reaction mechanism, spiro quaternary carbon stereocenters",

author = "Xu, \{Peng Wei\} and Yu, \{Jin Sheng\} and Chen Chen and Cao, \{Zhong Yan\} and Feng Zhou and Jian Zhou",

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AU - Xu, Peng Wei

AU - Yu, Jin Sheng

AU - Chen, Chen

AU - Cao, Zhong Yan

AU - Zhou, Feng

AU - Zhou, Jian

PY - 2019/3/1

Y1 - 2019/3/1

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AB - The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary carbon stereocenter is currently of great interest because such privileged 3D structures are widely present in natural products that exhibit a broad spectrum of biological and pharmacological activities. This review summarizes the advances based on six major synthetic strategies and showcases the reaction mechanisms in detail. The advantages and limitations of each synthetic strategy are presented, and the remaining synthetic opportunities are outlined.

KW - catalytic enantioselective

KW - metal catalysis

KW - organocatalysis

KW - reaction mechanism

KW - spiro quaternary carbon stereocenters

UR - https://www.scopus.com/pages/publications/85061261354

U2 - 10.1021/acscatal.8b03694

DO - 10.1021/acscatal.8b03694

M3 - 文章

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JF - ACS Catalysis

IS - 3

ER -

Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

Abstract

Keywords

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