Abstract
A Rh(II)/chiral phosphoric acid cocatalyzed four-component reaction of indoles, 3-diazooxindoles, arylamines, and ethyl glyoxylate is developed, offering an extremely efficient strategy for the construction of 3,3-disubstituted 3-indol-3′-yloxindoles with excellent diastereoselectivities and high to excellent enantioselectivities. This transformation is proposed to proceed through a Mannich-type trapping of the zwitterionic intermediate generated from a metal carbene and an indole with an iminoester derived from an arylamine and a glyoxylate.
| Original language | English |
|---|---|
| Pages (from-to) | 4336-4339 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 17 |
| Issue number | 17 |
| DOIs | |
| State | Published - 25 Aug 2015 |