Catalytic asymmetric acylcyanation of imines

Subhas Chandra Pan; Jian Zhou; Benjamin List

doi:10.1002/anie.200603630

Catalytic asymmetric acylcyanation of imines

Subhas Chandra Pan^*
, Jian Zhou
, Benjamin List

^*Corresponding author for this work

Max Planck Institute for Coal Research

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

(Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.

Original language	English
Pages (from-to)	612-614
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	4
DOIs	https://doi.org/10.1002/anie.200603630
State	Published - 2007
Externally published	Yes

Keywords

Acylcyanation
Asymmetric catalysis
Organocatalysis
Strecker reaction
Thiourea

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10.1002/anie.200603630

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title = "Catalytic asymmetric acylcyanation of imines",

abstract = "(Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.",

keywords = "Acylcyanation, Asymmetric catalysis, Organocatalysis, Strecker reaction, Thiourea",

author = "Pan, \{Subhas Chandra\} and Jian Zhou and Benjamin List",

year = "2007",

doi = "10.1002/anie.200603630",

language = "英语",

volume = "46",

pages = "612--614",

journal = "Angewandte Chemie - International Edition",

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T1 - Catalytic asymmetric acylcyanation of imines

AU - Pan, Subhas Chandra

AU - Zhou, Jian

AU - List, Benjamin

PY - 2007

Y1 - 2007

N2 - (Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.

AB - (Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.

KW - Acylcyanation

KW - Asymmetric catalysis

KW - Organocatalysis

KW - Strecker reaction

KW - Thiourea

UR - https://www.scopus.com/pages/publications/33846542040

U2 - 10.1002/anie.200603630

DO - 10.1002/anie.200603630

M3 - 文章

C2 - 17154433

AN - SCOPUS:33846542040

SN - 1433-7851

VL - 46

SP - 612

EP - 614

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 4

ER -

Catalytic asymmetric acylcyanation of imines

Abstract

Keywords

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