TY - JOUR
T1 - Catalyst-Enabled Chemodivergent Construction of Alkynyl- And Vinyl-Substituted Diarylmethanes from p-Quinone Methides and Alkynes
AU - Liu, Zhenli
AU - Xu, Haofeng
AU - Yao, Tengfei
AU - Zhang, Junliang
AU - Liu, Lu
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/9/20
Y1 - 2019/9/20
N2 - Here, a catalyst-controlled chemodivergent 1,6-addition of p-quinone methides with alkynes was developed, affording diverse alkynyl- and vinyl-substituted diarymethanes. In this transformation, copper catalyzed the direct 1,6-addition of p-QMs with alkynes, while iron promoted the three components reaction of p-QMs, alkynes, and halogens from iron salts or added HX acid. The salient features of this transformation include completely controllable chemoselectivity, mild conditions, inexpensive catalysts, and good substrates scopes.
AB - Here, a catalyst-controlled chemodivergent 1,6-addition of p-quinone methides with alkynes was developed, affording diverse alkynyl- and vinyl-substituted diarymethanes. In this transformation, copper catalyzed the direct 1,6-addition of p-QMs with alkynes, while iron promoted the three components reaction of p-QMs, alkynes, and halogens from iron salts or added HX acid. The salient features of this transformation include completely controllable chemoselectivity, mild conditions, inexpensive catalysts, and good substrates scopes.
UR - https://www.scopus.com/pages/publications/85072533220
U2 - 10.1021/acs.orglett.9b02810
DO - 10.1021/acs.orglett.9b02810
M3 - 文章
C2 - 31539927
AN - SCOPUS:85072533220
SN - 1523-7060
VL - 21
SP - 7539
EP - 7543
JO - Organic Letters
JF - Organic Letters
IS - 18
ER -