Cascade C-N bond cleavage of amides/intramolecular amination reactions: An atom economical way to α-cabolin-4-ones

Ye Wang; Zhong Zheng; Yang Yuan; Mengdan Wang; Zixia Guo; Yuan Ye Jiang; Li Ping Bai; Yanzhong Li

doi:10.1039/d0qo01257b

Cascade C-N bond cleavage of amides/intramolecular amination reactions: An atom economical way to α-cabolin-4-ones

Ye Wang
, Zhong Zheng
, Yang Yuan
, Mengdan Wang
, Zixia Guo
, Yuan Ye Jiang
, Li Ping Bai
, Yanzhong Li

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

An atom economical approach for the synthesis of α-carbolin-4-ones has been developed. This process was realized via a C-N bond cleavage/intramolecular amination cascade. During this process, one C-N and one C-C bond are cleaved and two C-N and two C-C bonds are formed. Mechanistic studies suggested a migrative N-cyclization process involving a carbene intermediate.

Original language	English
Pages (from-to)	579-583
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	8
Issue number	3
DOIs	https://doi.org/10.1039/d0qo01257b
State	Published - 7 Feb 2021

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abstract = "An atom economical approach for the synthesis of α-carbolin-4-ones has been developed. This process was realized via a C-N bond cleavage/intramolecular amination cascade. During this process, one C-N and one C-C bond are cleaved and two C-N and two C-C bonds are formed. Mechanistic studies suggested a migrative N-cyclization process involving a carbene intermediate.",

author = "Ye Wang and Zhong Zheng and Yang Yuan and Mengdan Wang and Zixia Guo and Jiang, \{Yuan Ye\} and Bai, \{Li Ping\} and Yanzhong Li",

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T1 - Cascade C-N bond cleavage of amides/intramolecular amination reactions

T2 - An atom economical way to α-cabolin-4-ones

AU - Wang, Ye

AU - Zheng, Zhong

AU - Yuan, Yang

AU - Wang, Mengdan

AU - Guo, Zixia

AU - Jiang, Yuan Ye

AU - Bai, Li Ping

AU - Li, Yanzhong

PY - 2021/2/7

Y1 - 2021/2/7

N2 - An atom economical approach for the synthesis of α-carbolin-4-ones has been developed. This process was realized via a C-N bond cleavage/intramolecular amination cascade. During this process, one C-N and one C-C bond are cleaved and two C-N and two C-C bonds are formed. Mechanistic studies suggested a migrative N-cyclization process involving a carbene intermediate.

AB - An atom economical approach for the synthesis of α-carbolin-4-ones has been developed. This process was realized via a C-N bond cleavage/intramolecular amination cascade. During this process, one C-N and one C-C bond are cleaved and two C-N and two C-C bonds are formed. Mechanistic studies suggested a migrative N-cyclization process involving a carbene intermediate.

UR - https://www.scopus.com/pages/publications/85100791457

U2 - 10.1039/d0qo01257b

DO - 10.1039/d0qo01257b

M3 - 文章

AN - SCOPUS:85100791457

SN - 2052-4110

VL - 8

SP - 579

EP - 583

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 3

ER -

Cascade C-N bond cleavage of amides/intramolecular amination reactions: An atom economical way to α-cabolin-4-ones

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