Carrier-free supramolecular nanomedicines assembled by small-molecule therapeutics for cancer treatment

Jianhui Zuo; Xin Gao; Jianru Xiao; Yiyun Cheng

doi:10.1016/j.cclet.2022.107827

Carrier-free supramolecular nanomedicines assembled by small-molecule therapeutics for cancer treatment

Jianhui Zuo
, Xin Gao
, Jianru Xiao^*
, Yiyun Cheng

^*Corresponding author for this work

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Nanomedicines have shown great promise in cancer therapy, but are challenged by limited drug loading, safety concerns of drug carriers, and complexity of function integration. Recently, carrier-free nanomedicines produced by supramolecular assembly of small-molecule therapeutic functionalities and their conjugates were proposed to address these issues. These nanomedicines achieve very high drug loading, enhanced tumor accumulation and improved therapeutic efficiency, and avoid carrier-related safety problems. In this review article, the applications of these nanomedicines in chemotherapy, photodynamic therapy, photothermal therapy as well as combination therapies will be reviewed. The concept of nanomedicine design and mechanism of supramolecular assembly will be discussed. Finally, future perspectives of carrier-free supramolecular nanomedicines for cancer therapy will be highlighted.

Original language	English
Article number	107827
Journal	Chinese Chemical Letters
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.cclet.2022.107827
State	Published - May 2023

Keywords

Cancer therapy
Carrier-free
Combination therapy
Nanomedicine
Supramolecular assembly

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cclet.2022.107827

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title = "Carrier-free supramolecular nanomedicines assembled by small-molecule therapeutics for cancer treatment",

abstract = "Nanomedicines have shown great promise in cancer therapy, but are challenged by limited drug loading, safety concerns of drug carriers, and complexity of function integration. Recently, carrier-free nanomedicines produced by supramolecular assembly of small-molecule therapeutic functionalities and their conjugates were proposed to address these issues. These nanomedicines achieve very high drug loading, enhanced tumor accumulation and improved therapeutic efficiency, and avoid carrier-related safety problems. In this review article, the applications of these nanomedicines in chemotherapy, photodynamic therapy, photothermal therapy as well as combination therapies will be reviewed. The concept of nanomedicine design and mechanism of supramolecular assembly will be discussed. Finally, future perspectives of carrier-free supramolecular nanomedicines for cancer therapy will be highlighted.",

keywords = "Cancer therapy, Carrier-free, Combination therapy, Nanomedicine, Supramolecular assembly",

author = "Jianhui Zuo and Xin Gao and Jianru Xiao and Yiyun Cheng",

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year = "2023",

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doi = "10.1016/j.cclet.2022.107827",

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volume = "34",

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TY - JOUR

T1 - Carrier-free supramolecular nanomedicines assembled by small-molecule therapeutics for cancer treatment

AU - Zuo, Jianhui

AU - Gao, Xin

AU - Xiao, Jianru

AU - Cheng, Yiyun

PY - 2023/5

Y1 - 2023/5

N2 - Nanomedicines have shown great promise in cancer therapy, but are challenged by limited drug loading, safety concerns of drug carriers, and complexity of function integration. Recently, carrier-free nanomedicines produced by supramolecular assembly of small-molecule therapeutic functionalities and their conjugates were proposed to address these issues. These nanomedicines achieve very high drug loading, enhanced tumor accumulation and improved therapeutic efficiency, and avoid carrier-related safety problems. In this review article, the applications of these nanomedicines in chemotherapy, photodynamic therapy, photothermal therapy as well as combination therapies will be reviewed. The concept of nanomedicine design and mechanism of supramolecular assembly will be discussed. Finally, future perspectives of carrier-free supramolecular nanomedicines for cancer therapy will be highlighted.

AB - Nanomedicines have shown great promise in cancer therapy, but are challenged by limited drug loading, safety concerns of drug carriers, and complexity of function integration. Recently, carrier-free nanomedicines produced by supramolecular assembly of small-molecule therapeutic functionalities and their conjugates were proposed to address these issues. These nanomedicines achieve very high drug loading, enhanced tumor accumulation and improved therapeutic efficiency, and avoid carrier-related safety problems. In this review article, the applications of these nanomedicines in chemotherapy, photodynamic therapy, photothermal therapy as well as combination therapies will be reviewed. The concept of nanomedicine design and mechanism of supramolecular assembly will be discussed. Finally, future perspectives of carrier-free supramolecular nanomedicines for cancer therapy will be highlighted.

KW - Cancer therapy

KW - Carrier-free

KW - Combination therapy

KW - Nanomedicine

KW - Supramolecular assembly

UR - https://www.scopus.com/pages/publications/85148858288

U2 - 10.1016/j.cclet.2022.107827

DO - 10.1016/j.cclet.2022.107827

M3 - 文章

AN - SCOPUS:85148858288

SN - 1001-8417

VL - 34

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 5

M1 - 107827

ER -

Carrier-free supramolecular nanomedicines assembled by small-molecule therapeutics for cancer treatment

Abstract

Keywords

UN SDGs

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