Brønsted acid catalysed chemo- andortho-selective aminomethylation of phenol

Zhiqiong Tang; Dongdong Li; Yidi Yue; Dan Peng; Lu Liu

doi:10.1039/d1ob00820j

Brønsted acid catalysed chemo- andortho-selective aminomethylation of phenol

Zhiqiong Tang
, Dongdong Li
, Yidi Yue
, Dan Peng
, Lu Liu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We have developed a Brønsted acid catalysed highlyortho-selective functionalization of free phenols with readily availableN,O-acetals under mild conditions, furnishing various corresponding aminomethylated phenol products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellentortho-selectivity, high efficiency, and ease of further transformation.

Original language	English
Pages (from-to)	5777-5781
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	19
Issue number	26
DOIs	https://doi.org/10.1039/d1ob00820j
State	Published - 14 Jul 2021

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10.1039/d1ob00820j

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title = "Br{\o}nsted acid catalysed chemo- andortho-selective aminomethylation of phenol",

abstract = "We have developed a Br{\o}nsted acid catalysed highlyortho-selective functionalization of free phenols with readily availableN,O-acetals under mild conditions, furnishing various corresponding aminomethylated phenol products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellentortho-selectivity, high efficiency, and ease of further transformation.",

author = "Zhiqiong Tang and Dongdong Li and Yidi Yue and Dan Peng and Lu Liu",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

year = "2021",

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day = "14",

doi = "10.1039/d1ob00820j",

language = "英语",

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T1 - Brønsted acid catalysed chemo- andortho-selective aminomethylation of phenol

AU - Tang, Zhiqiong

AU - Li, Dongdong

AU - Yue, Yidi

AU - Peng, Dan

AU - Liu, Lu

PY - 2021/7/14

Y1 - 2021/7/14

N2 - We have developed a Brønsted acid catalysed highlyortho-selective functionalization of free phenols with readily availableN,O-acetals under mild conditions, furnishing various corresponding aminomethylated phenol products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellentortho-selectivity, high efficiency, and ease of further transformation.

AB - We have developed a Brønsted acid catalysed highlyortho-selective functionalization of free phenols with readily availableN,O-acetals under mild conditions, furnishing various corresponding aminomethylated phenol products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellentortho-selectivity, high efficiency, and ease of further transformation.

UR - https://www.scopus.com/pages/publications/85109268482

U2 - 10.1039/d1ob00820j

DO - 10.1039/d1ob00820j

M3 - 文章

C2 - 34156058

AN - SCOPUS:85109268482

SN - 1477-0520

VL - 19

SP - 5777

EP - 5781

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 26

ER -

Brønsted acid catalysed chemo- andortho-selective aminomethylation of phenol

Abstract

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