Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

Jianye Fu; Zhengying Gu; Yang Liu; Jun Zhang; Hao Song; Yannan Yang; Yang Yang; Owen Noonan; Jie Tang; Chengzhong Yu

doi:10.1039/c9sc02961c

Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

Jianye Fu
, Zhengying Gu
, Yang Liu
, Jun Zhang
, Hao Song
, Yannan Yang
, Yang Yang
, Owen Noonan
, Jie Tang
, Chengzhong Yu

School of Chemistry and Molecular Engineering

University of Queensland

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.

Original language	English
Pages (from-to)	10388-10394
Number of pages	7
Journal	Chemical Science
Volume	10
Issue number	44
DOIs	https://doi.org/10.1039/c9sc02961c
State	Published - 2019

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10.1039/c9sc02961c

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title = "Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations",

abstract = "A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.",

author = "Jianye Fu and Zhengying Gu and Yang Liu and Jun Zhang and Hao Song and Yannan Yang and Yang Yang and Owen Noonan and Jie Tang and Chengzhong Yu",

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year = "2019",

doi = "10.1039/c9sc02961c",

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volume = "10",

pages = "10388--10394",

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T1 - Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

AU - Fu, Jianye

AU - Gu, Zhengying

AU - Liu, Yang

AU - Zhang, Jun

AU - Song, Hao

AU - Yang, Yannan

AU - Yang, Yang

AU - Noonan, Owen

AU - Tang, Jie

AU - Yu, Chengzhong

PY - 2019

Y1 - 2019

N2 - A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.

AB - A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.

UR - https://www.scopus.com/pages/publications/85075084116

U2 - 10.1039/c9sc02961c

DO - 10.1039/c9sc02961c

M3 - 文章

AN - SCOPUS:85075084116

SN - 2041-6520

VL - 10

SP - 10388

EP - 10394

JO - Chemical Science

JF - Chemical Science

IS - 44

ER -

Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

Abstract

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