TY - JOUR
T1 - Both Val158Met Polymorphism of Catechol-O-Methyltransferase Gene and Menstrual Cycle Affect Prepulse Inhibition but Not Attentional Modulation of Prepulse Inhibition in Younger-Adult Females
AU - Wu, Chao
AU - Ding, Yu
AU - Chen, Biqing
AU - Gao, Yayue
AU - Wang, Qian
AU - Wu, Zhemeng
AU - Lu, Lingxi
AU - Luo, Lu
AU - Zhang, Changxin
AU - Bao, Xiaohan
AU - Yang, Pengcheng
AU - Fan, Langchen
AU - Lei, Ming
AU - Li, Liang
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Prepulse inhibition (PPI) can be modulated by both the Val158Met (rs4680) polymorphism of the Catechol-O-Methyltransferase (COMT) gene and the menstrual-cycle-related hormone fluctuations, each of which affects the subcortical/cortical dopamine metabolism. PPI can also be modulated by attention. The attentional modulation of PPI (AMPPI) is sensitive to psychoses. Whether the Val158Met polymorphism affects the AMPPI in female adults at different menstrual-cycle phases is unknown. This study examined whether AMPPI and/or PPI are affected by the Val158Met polymorphism in 177 younger-adult females whose menstrual cycles were mutually different across the menstruation, proliferative, or secretory phases. The AMPPI was evaluated by comparing PPI under the condition of the auditory precedence-effect-induced perceptual spatial separation between the prepulse stimulus and a masking noise (PPI PSS ) against that under the condition of the precedence-effect-induced perceptual spatial co-location (PPI PSC ). The results showed that both the menstrual cycle and the COMT Val158Met polymorphism affected both PPI PSC and PPI PSS , but not the AMPPI (difference between PPI PSS and PPI PSC ). Moreover, throughout the menstrual cycle, both PPI PSC and PPI PSS decreased monotonously in Val/Val-carrier participants. However, the decreasing pattern was not overserved in either Met/Met-carrier or Met/Val-carrier participants. Thus, in healthy younger-adult females, PPI PSC and PPI PSS , but not the AMPPI, is vulnerable to changes of ovarian hormones, and the COMT Val158Met polymorphism also has a modulating effect on this menstrual-cycle-dependent PPI variation. In contrast, the AMPPI seems to be more steadily trait-based, less vulnerable to ovarian hormone fluctuations, and may be useful in assisting the diagnosis of schizophrenia in female adults.
AB - Prepulse inhibition (PPI) can be modulated by both the Val158Met (rs4680) polymorphism of the Catechol-O-Methyltransferase (COMT) gene and the menstrual-cycle-related hormone fluctuations, each of which affects the subcortical/cortical dopamine metabolism. PPI can also be modulated by attention. The attentional modulation of PPI (AMPPI) is sensitive to psychoses. Whether the Val158Met polymorphism affects the AMPPI in female adults at different menstrual-cycle phases is unknown. This study examined whether AMPPI and/or PPI are affected by the Val158Met polymorphism in 177 younger-adult females whose menstrual cycles were mutually different across the menstruation, proliferative, or secretory phases. The AMPPI was evaluated by comparing PPI under the condition of the auditory precedence-effect-induced perceptual spatial separation between the prepulse stimulus and a masking noise (PPI PSS ) against that under the condition of the precedence-effect-induced perceptual spatial co-location (PPI PSC ). The results showed that both the menstrual cycle and the COMT Val158Met polymorphism affected both PPI PSC and PPI PSS , but not the AMPPI (difference between PPI PSS and PPI PSC ). Moreover, throughout the menstrual cycle, both PPI PSC and PPI PSS decreased monotonously in Val/Val-carrier participants. However, the decreasing pattern was not overserved in either Met/Met-carrier or Met/Val-carrier participants. Thus, in healthy younger-adult females, PPI PSC and PPI PSS , but not the AMPPI, is vulnerable to changes of ovarian hormones, and the COMT Val158Met polymorphism also has a modulating effect on this menstrual-cycle-dependent PPI variation. In contrast, the AMPPI seems to be more steadily trait-based, less vulnerable to ovarian hormone fluctuations, and may be useful in assisting the diagnosis of schizophrenia in female adults.
KW - Val153Met polymorphism
KW - attentional modulation
KW - menstrual cycle
KW - perceived spatial separation
KW - precedence effect
KW - prepulse inhibition
UR - https://www.scopus.com/pages/publications/85062444568
U2 - 10.1016/j.neuroscience.2019.02.001
DO - 10.1016/j.neuroscience.2019.02.001
M3 - 文章
C2 - 30742958
AN - SCOPUS:85062444568
SN - 0306-4522
VL - 404
SP - 396
EP - 406
JO - Neuroscience
JF - Neuroscience
ER -