Abstract
Introduction: Delivery of therapeutic agents to bone is crucial for the treatment of bone metastasis and other bone diseases. The present invention patent relates to bone- and metal-targeted polymeric nanoparticles for targeting delivery of therapeutic molecules to the pathological tissues in bone or the surgical metal implant-bone tissue interface. Areas covered: The nanoparticles for drug delivery were fabricated via the assembly of amphiphilic polymers, in which the hydrophilic outer layer was minimal to prolong the circulation time, and the hydrophobic insider core was biodegradable and loaded with therapeutic agents. Bone-targeted elements were conjugated on the nanoparticle surface to enhance their affinity to bone and/or metal implant surface. Expert opinion: A prolonged, sustained release of therapeutic agents was observed by using the delivery system targeting to bone. The described invention provides a bone-targeted vector to deliver diverse therapeutic agents to bone.
| Original language | English |
|---|---|
| Pages (from-to) | 987-991 |
| Number of pages | 5 |
| Journal | Expert Opinion on Therapeutic Patents |
| Volume | 26 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1 Sep 2016 |
Keywords
- Bone targeting
- bone metastases
- bone-related diseases
- drug delivery
- polymeric nanoparticles