TY - JOUR
T1 - Biomarkers of aging
AU - Aging Biomarker Consortium
AU - Bao, Hainan
AU - Cao, Jiani
AU - Chen, Mengting
AU - Chen, Min
AU - Chen, Wei
AU - Chen, Xiao
AU - Chen, Yanhao
AU - Chen, Yu
AU - Chen, Yutian
AU - Chen, Zhiyang
AU - Chhetri, Jagadish K.
AU - Ding, Yingjie
AU - Feng, Junlin
AU - Guo, Jun
AU - Guo, Mengmeng
AU - He, Chuting
AU - Jia, Yujuan
AU - Jiang, Haiping
AU - Jing, Ying
AU - Li, Dingfeng
AU - Li, Jiaming
AU - Li, Jingyi
AU - Liang, Qinhao
AU - Liang, Rui
AU - Liu, Feng
AU - Liu, Xiaoqian
AU - Liu, Zuojun
AU - Luo, Oscar Junhong
AU - Lv, Jianwei
AU - Ma, Jingyi
AU - Mao, Kehang
AU - Nie, Jiawei
AU - Qiao, Xinhua
AU - Sun, Xinpei
AU - Tang, Xiaoqiang
AU - Wang, Jianfang
AU - Wang, Qiaoran
AU - Wang, Siyuan
AU - Wang, Xuan
AU - Wang, Yaning
AU - Wang, Yuhan
AU - Wu, Rimo
AU - Xia, Kai
AU - Xiao, Fu Hui
AU - Xu, Lingyan
AU - Xu, Yingying
AU - Yan, Haoteng
AU - Yang, Liang
AU - Yang, Ruici
AU - Ma, Xinran
N1 - Publisher Copyright:
© 2023, Science China Press.
PY - 2023/5
Y1 - 2023/5
N2 - Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.
AB - Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.
KW - aging
KW - biomarker
KW - clock
KW - senescence
UR - https://www.scopus.com/pages/publications/85153290053
U2 - 10.1007/s11427-023-2305-0
DO - 10.1007/s11427-023-2305-0
M3 - 文献综述
C2 - 37076725
AN - SCOPUS:85153290053
SN - 1674-7305
VL - 66
SP - 893
EP - 1066
JO - Science China Life Sciences
JF - Science China Life Sciences
IS - 5
ER -