Biocompatible Inorganic Nanoagent for Efficient Synergistic Tumor Treatment with Augmented Antitumor Immunity

Synergistic therapy for malignant tumors has been developed in the past. However, several disadvantages that are associated with the applied inorganic nanoagents cannot be avoided, including intrinsic systemic toxicity, immunosuppression, and low therapeutic efficiency. Herein, a biocompatible, multifunctional, inorganic nanoagent that simultaneously integrates chemodynamic, starvation, and photothermal therapies is developed. This nanoagent effectively converts endogenous H₂O₂ into highly toxic hydroxyl radicals via the Fenton reaction. Self-reinforced cancer therapy is achieved via the scavenging of intracellular glutathione and glucose. The encapsulation of nanoagent by erythrocytes drastically reduces its immune recognition by macrophages. Thus, an augmented anti-tumor immune response is realized. Moreover, in contrast to traditional inorganic chemodynamic nanomaterials, the nanoagent has outstanding photothermal efficiency. Therefore, the present system exhibits an effective tumor therapeutic outcome. This work may facilitate a new pathway for the development of highly efficacious synergetic therapies.