Berberine analogues: Progress towards versatile applications

Jing Wang; Jie Tang; Li Fang Yu; Jia Li; Jing Ya Li; Fan Yang

doi:10.3987/REV-15-825

Berberine analogues: Progress towards versatile applications

Jing Wang
, Jie Tang
, Li Fang Yu
, Jia Li
, Jing Ya Li
, Fan Yang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
CAS - Shanghai Institute of Materia Medica

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The promising activities shown by analogues of natural product berberine in numerous categories such as anti-hyperglycaemic, anti-cancer, anti-inflammatory, anti-Alzheimer's disease and anti-microbials, have made it an indispensable structure for development of new therapeutic agents. The compounds bearing various substituents on the berberine skeleton have exhibited a wide spectrum of biological activities. Short reviews on biological importance of this core structure have been showcased in literature. However, systematic review on the research advances of structure-activity relationship of berberine and its analogues seems lacking. In the present review, various analogues of berberine with different pharmacological activities were summarized and their SAR were discussed as well. The current review would provide useful information for further studies on structural modifications on berberine for discovering new drug leads.

Original language	English
Pages (from-to)	2233-2270
Number of pages	38
Journal	Heterocycles
Volume	91
Issue number	12
DOIs	https://doi.org/10.3987/REV-15-825
State	Published - 2015

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title = "Berberine analogues: Progress towards versatile applications",

abstract = "The promising activities shown by analogues of natural product berberine in numerous categories such as anti-hyperglycaemic, anti-cancer, anti-inflammatory, anti-Alzheimer's disease and anti-microbials, have made it an indispensable structure for development of new therapeutic agents. The compounds bearing various substituents on the berberine skeleton have exhibited a wide spectrum of biological activities. Short reviews on biological importance of this core structure have been showcased in literature. However, systematic review on the research advances of structure-activity relationship of berberine and its analogues seems lacking. In the present review, various analogues of berberine with different pharmacological activities were summarized and their SAR were discussed as well. The current review would provide useful information for further studies on structural modifications on berberine for discovering new drug leads.",

author = "Jing Wang and Jie Tang and Yu, \{Li Fang\} and Jia Li and Li, \{Jing Ya\} and Fan Yang",

note = "Publisher Copyright: {\textcopyright} 2015 The Japan Institute of Heterocyclic Chemistry.",

year = "2015",

doi = "10.3987/REV-15-825",

language = "英语",

volume = "91",

pages = "2233--2270",

journal = "Heterocycles",

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TY - JOUR

T1 - Berberine analogues

T2 - Progress towards versatile applications

AU - Wang, Jing

AU - Tang, Jie

AU - Yu, Li Fang

AU - Li, Jia

AU - Li, Jing Ya

AU - Yang, Fan

PY - 2015

Y1 - 2015

N2 - The promising activities shown by analogues of natural product berberine in numerous categories such as anti-hyperglycaemic, anti-cancer, anti-inflammatory, anti-Alzheimer's disease and anti-microbials, have made it an indispensable structure for development of new therapeutic agents. The compounds bearing various substituents on the berberine skeleton have exhibited a wide spectrum of biological activities. Short reviews on biological importance of this core structure have been showcased in literature. However, systematic review on the research advances of structure-activity relationship of berberine and its analogues seems lacking. In the present review, various analogues of berberine with different pharmacological activities were summarized and their SAR were discussed as well. The current review would provide useful information for further studies on structural modifications on berberine for discovering new drug leads.

AB - The promising activities shown by analogues of natural product berberine in numerous categories such as anti-hyperglycaemic, anti-cancer, anti-inflammatory, anti-Alzheimer's disease and anti-microbials, have made it an indispensable structure for development of new therapeutic agents. The compounds bearing various substituents on the berberine skeleton have exhibited a wide spectrum of biological activities. Short reviews on biological importance of this core structure have been showcased in literature. However, systematic review on the research advances of structure-activity relationship of berberine and its analogues seems lacking. In the present review, various analogues of berberine with different pharmacological activities were summarized and their SAR were discussed as well. The current review would provide useful information for further studies on structural modifications on berberine for discovering new drug leads.

UR - https://www.scopus.com/pages/publications/84958974456

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DO - 10.3987/REV-15-825

M3 - 文章

AN - SCOPUS:84958974456

SN - 0385-5414

VL - 91

SP - 2233

EP - 2270

JO - Heterocycles

JF - Heterocycles

IS - 12

ER -

Berberine analogues: Progress towards versatile applications

Abstract

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