Base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines

Qiongwen Kang; Mengdan Wang; Zongkang Wang; Lu Cheng; Yilin Zhu; Chengyu Wang; Yanzhong Li

doi:10.1039/d3qo00818e

Base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines

Qiongwen Kang, Mengdan Wang, Zongkang Wang, Lu Cheng, Yilin Zhu, Chengyu Wang, Yanzhong Li

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines under mild conditions has been developed. This is the first example of a transition-metal free ring-expansion reaction of indolones via the selective insertion of alkynoates into the C2-N1 bond. The process achieved the cleavage of one C-N bond and three C-C bonds, and the formation of one C-N and three C-C bonds in one step.

Original language	English
Pages (from-to)	5205-5209
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	10
Issue number	20
DOIs	https://doi.org/10.1039/d3qo00818e
State	Published - 5 Sep 2023

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title = "Base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines",

abstract = "A base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines under mild conditions has been developed. This is the first example of a transition-metal free ring-expansion reaction of indolones via the selective insertion of alkynoates into the C2-N1 bond. The process achieved the cleavage of one C-N bond and three C-C bonds, and the formation of one C-N and three C-C bonds in one step.",

author = "Qiongwen Kang and Mengdan Wang and Zongkang Wang and Lu Cheng and Yilin Zhu and Chengyu Wang and Yanzhong Li",

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T1 - Base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines

AU - Kang, Qiongwen

AU - Wang, Mengdan

AU - Wang, Zongkang

AU - Cheng, Lu

AU - Zhu, Yilin

AU - Wang, Chengyu

AU - Li, Yanzhong

PY - 2023/9/5

Y1 - 2023/9/5

N2 - A base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines under mild conditions has been developed. This is the first example of a transition-metal free ring-expansion reaction of indolones via the selective insertion of alkynoates into the C2-N1 bond. The process achieved the cleavage of one C-N bond and three C-C bonds, and the formation of one C-N and three C-C bonds in one step.

AB - A base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines under mild conditions has been developed. This is the first example of a transition-metal free ring-expansion reaction of indolones via the selective insertion of alkynoates into the C2-N1 bond. The process achieved the cleavage of one C-N bond and three C-C bonds, and the formation of one C-N and three C-C bonds in one step.

UR - https://www.scopus.com/pages/publications/85171672124

U2 - 10.1039/d3qo00818e

DO - 10.1039/d3qo00818e

M3 - 文章

AN - SCOPUS:85171672124

SN - 2052-4110

VL - 10

SP - 5205

EP - 5209

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 20

ER -

Base-promoted selective C2-N1 ring-expansion reaction of indolones toward substituted quinolines

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