Base-Promoted Intermolecular Trifluoroacetyl Amination of Alkynes via C−N Cleavage of Amides: An Atom-Economic Way to Trifluoromethyl-Containing Tetrasubstituted Olefin Derivatives

A novel base-promoted and highly efficient strategy for preparation of trifluoromethyl-containing tetrasubstituted olefin derivatives has been developed. The trifluoroacetyl amination of alkynes is realized by C−N cleavage of trifluoroacetamides without any transition-metal catalysts. Readily accessible substrates, good functional group tolerance and atom economy make this approach attractive for the synthesis of trifluoromethyl-containing tetrasubstituted olefins.