Asymmetric Synthesis of Rugulotrosin A

Jianhua Chen; Yayue Li; Zheming Xiao; Haibing He; Shuanhu Gao

doi:10.1021/acs.orglett.0c00063

Asymmetric Synthesis of Rugulotrosin A

Jianhua Chen, Yayue Li, Zheming Xiao, Haibing He, Shuanhu Gao

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetrahydroxanthones bearing different functional groups at C-12. As a synthetic application, the asymmetric formal synthesis of rugulotrosin A was achieved.

Original language	English
Pages (from-to)	1485-1489
Number of pages	5
Journal	Organic Letters
Volume	22
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.0c00063
State	Published - 21 Feb 2020

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10.1021/acs.orglett.0c00063

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title = "Asymmetric Synthesis of Rugulotrosin A",

abstract = "A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetrahydroxanthones bearing different functional groups at C-12. As a synthetic application, the asymmetric formal synthesis of rugulotrosin A was achieved.",

author = "Jianhua Chen and Yayue Li and Zheming Xiao and Haibing He and Shuanhu Gao",

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T1 - Asymmetric Synthesis of Rugulotrosin A

AU - Chen, Jianhua

AU - Li, Yayue

AU - Xiao, Zheming

AU - He, Haibing

AU - Gao, Shuanhu

PY - 2020/2/21

Y1 - 2020/2/21

N2 - A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetrahydroxanthones bearing different functional groups at C-12. As a synthetic application, the asymmetric formal synthesis of rugulotrosin A was achieved.

AB - A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetrahydroxanthones bearing different functional groups at C-12. As a synthetic application, the asymmetric formal synthesis of rugulotrosin A was achieved.

UR - https://www.scopus.com/pages/publications/85081142552

U2 - 10.1021/acs.orglett.0c00063

DO - 10.1021/acs.orglett.0c00063

M3 - 文章

C2 - 32037839

AN - SCOPUS:85081142552

SN - 1523-7060

VL - 22

SP - 1485

EP - 1489

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Asymmetric Synthesis of Rugulotrosin A

Abstract

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