Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes: In vivo

Min Li; Chuanfeng Wang; Ting Wang; Mengting Fan; Ning Wang; Danying Ma; Ting Hu; Xiaoyan Cui

doi:10.1039/c9cc09666c

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes: In vivo

Min Li, Chuanfeng Wang, Ting Wang, Mengting Fan, Ning Wang, Danying Ma, Ting Hu, Xiaoyan Cui

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.

Original language	English
Pages (from-to)	2455-2458
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	16
DOIs	https://doi.org/10.1039/c9cc09666c
State	Published - 25 Feb 2020

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title = "Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes: In vivo",

abstract = "A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.",

author = "Min Li and Chuanfeng Wang and Ting Wang and Mengting Fan and Ning Wang and Danying Ma and Ting Hu and Xiaoyan Cui",

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T1 - Asymmetric Si-rhodamine scaffolds

T2 - rational design of pH-durable protease-activated NIR probes: In vivo

AU - Li, Min

AU - Wang, Chuanfeng

AU - Wang, Ting

AU - Fan, Mengting

AU - Wang, Ning

AU - Ma, Danying

AU - Hu, Ting

AU - Cui, Xiaoyan

PY - 2020/2/25

Y1 - 2020/2/25

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AB - A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.

UR - https://www.scopus.com/pages/publications/85080121087

U2 - 10.1039/c9cc09666c

DO - 10.1039/c9cc09666c

M3 - 文章

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AN - SCOPUS:85080121087

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SP - 2455

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JF - Chemical Communications

IS - 16

ER -

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes: In vivo

Abstract

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