Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis

Lu Liu; Ryan Sarkisian; Zhenghu Xu; Hong Wang

doi:10.1021/jo301070s

Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis

Lu Liu
, Ryan Sarkisian
, Zhenghu Xu^*
, Hong Wang

^*Corresponding author for this work

Miami University
Shandong University

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.

Original language	English
Pages (from-to)	7693-7699
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	77
Issue number	17
DOIs	https://doi.org/10.1021/jo301070s
State	Published - 7 Sep 2012
Externally published	Yes

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title = "Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis",

abstract = "Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99\% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.",

author = "Lu Liu and Ryan Sarkisian and Zhenghu Xu and Hong Wang",

year = "2012",

month = sep,

day = "7",

doi = "10.1021/jo301070s",

language = "英语",

volume = "77",

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journal = "Journal of Organic Chemistry",

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T1 - Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis

AU - Liu, Lu

AU - Sarkisian, Ryan

AU - Xu, Zhenghu

AU - Wang, Hong

PY - 2012/9/7

Y1 - 2012/9/7

N2 - Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.

AB - Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.

UR - https://www.scopus.com/pages/publications/84866119352

U2 - 10.1021/jo301070s

DO - 10.1021/jo301070s

M3 - 文章

C2 - 22877155

AN - SCOPUS:84866119352

SN - 0022-3263

VL - 77

SP - 7693

EP - 7699

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 17

ER -

Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis

Abstract

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