Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite

Jinzhu Zhang; Kaiwu Dong; Zheng Wang; Kuiling Ding

doi:10.1039/c1ob06835k

Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite

Jinzhu Zhang
, Kaiwu Dong
, Zheng Wang
, Kuiling Ding^*

^*Corresponding author for this work

CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The Rh(i) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β- unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99% ee).

Original language	English
Pages (from-to)	1598-1601
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	8
DOIs	https://doi.org/10.1039/c1ob06835k
State	Published - 28 Feb 2012
Externally published	Yes

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title = "Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite",

abstract = "The Rh(i) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β- unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99\% ee).",

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AU - Zhang, Jinzhu

AU - Dong, Kaiwu

AU - Wang, Zheng

AU - Ding, Kuiling

PY - 2012/2/28

Y1 - 2012/2/28

N2 - The Rh(i) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β- unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99% ee).

AB - The Rh(i) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β- unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99% ee).

UR - https://www.scopus.com/pages/publications/84863115613

U2 - 10.1039/c1ob06835k

DO - 10.1039/c1ob06835k

M3 - 文章

C2 - 22218565

AN - SCOPUS:84863115613

SN - 1477-0520

VL - 10

SP - 1598

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 8

ER -

Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite

Abstract

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