Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand

Kaiwu Dong; Yang Li; Zheng Wang; Kuiling Ding

doi:10.1039/c3qo00042g

Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand

Kaiwu Dong, Yang Li, Zheng Wang, Kuiling Ding

CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The Rh^I complexes of chiral secondary phosphine oxide ligands have been disclosed to be efficient for the catalytic asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids, providing the corresponding chiral α-arylpropanoic and β-arylbutanoic acids in excellent yields with up to 97% ee, including several anti-inflammatory drugs.

Original language	English
Pages (from-to)	155-160
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	1
Issue number	2
DOIs	https://doi.org/10.1039/c3qo00042g
State	Published - 1 Apr 2014
Externally published	Yes

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title = "Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand",

abstract = "The RhI complexes of chiral secondary phosphine oxide ligands have been disclosed to be efficient for the catalytic asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids, providing the corresponding chiral α-arylpropanoic and β-arylbutanoic acids in excellent yields with up to 97\% ee, including several anti-inflammatory drugs.",

author = "Kaiwu Dong and Yang Li and Zheng Wang and Kuiling Ding",

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doi = "10.1039/c3qo00042g",

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T1 - Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand

AU - Dong, Kaiwu

AU - Li, Yang

AU - Wang, Zheng

AU - Ding, Kuiling

PY - 2014/4/1

Y1 - 2014/4/1

N2 - The RhI complexes of chiral secondary phosphine oxide ligands have been disclosed to be efficient for the catalytic asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids, providing the corresponding chiral α-arylpropanoic and β-arylbutanoic acids in excellent yields with up to 97% ee, including several anti-inflammatory drugs.

AB - The RhI complexes of chiral secondary phosphine oxide ligands have been disclosed to be efficient for the catalytic asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids, providing the corresponding chiral α-arylpropanoic and β-arylbutanoic acids in excellent yields with up to 97% ee, including several anti-inflammatory drugs.

UR - https://www.scopus.com/pages/publications/84934978209

U2 - 10.1039/c3qo00042g

DO - 10.1039/c3qo00042g

M3 - 文章

AN - SCOPUS:84934978209

SN - 2052-4110

VL - 1

SP - 155

EP - 160

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 2

ER -

Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand

Abstract

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