Asymmetric copper(I)-catalyzed azide-alkyne cycloaddition to quaternary oxindoles

Feng Zhou; Chen Tan; Jing Tang; Yan Yan Zhang; Wei Ming Gao; Hai Hong Wu; Yi Hua Yu; Jian Zhou

doi:10.1021/ja4066656

Asymmetric copper(I)-catalyzed azide-alkyne cycloaddition to quaternary oxindoles

Feng Zhou
, Chen Tan
, Jing Tang
, Yan Yan Zhang
, Wei Ming Gao
, Hai Hong Wu
, Yi Hua Yu
, Jian Zhou^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

Abstract

We report a highly enantioselective Cu(I)-catalyzed azide-alkyne cycloaddition via asymmetric desymmetrization of oxindole-based 1,6-heptadiynes, which furnishes quaternary oxindoles bearing a 1,2,3-triazole-containing moiety with 84-98% ee.

Original language	English
Pages (from-to)	10994-10997
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	30
DOIs	https://doi.org/10.1021/ja4066656
State	Published - 31 Jul 2013

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title = "Asymmetric copper(I)-catalyzed azide-alkyne cycloaddition to quaternary oxindoles",

abstract = "We report a highly enantioselective Cu(I)-catalyzed azide-alkyne cycloaddition via asymmetric desymmetrization of oxindole-based 1,6-heptadiynes, which furnishes quaternary oxindoles bearing a 1,2,3-triazole-containing moiety with 84-98\% ee.",

author = "Feng Zhou and Chen Tan and Jing Tang and Zhang, \{Yan Yan\} and Gao, \{Wei Ming\} and Wu, \{Hai Hong\} and Yu, \{Yi Hua\} and Jian Zhou",

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day = "31",

doi = "10.1021/ja4066656",

language = "英语",

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T1 - Asymmetric copper(I)-catalyzed azide-alkyne cycloaddition to quaternary oxindoles

AU - Zhou, Feng

AU - Tan, Chen

AU - Tang, Jing

AU - Zhang, Yan Yan

AU - Gao, Wei Ming

AU - Wu, Hai Hong

AU - Yu, Yi Hua

AU - Zhou, Jian

PY - 2013/7/31

Y1 - 2013/7/31

N2 - We report a highly enantioselective Cu(I)-catalyzed azide-alkyne cycloaddition via asymmetric desymmetrization of oxindole-based 1,6-heptadiynes, which furnishes quaternary oxindoles bearing a 1,2,3-triazole-containing moiety with 84-98% ee.

AB - We report a highly enantioselective Cu(I)-catalyzed azide-alkyne cycloaddition via asymmetric desymmetrization of oxindole-based 1,6-heptadiynes, which furnishes quaternary oxindoles bearing a 1,2,3-triazole-containing moiety with 84-98% ee.

UR - https://www.scopus.com/pages/publications/84881074856

U2 - 10.1021/ja4066656

DO - 10.1021/ja4066656

M3 - 文章

AN - SCOPUS:84881074856

SN - 0002-7863

VL - 135

SP - 10994

EP - 10997

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 30

ER -

Asymmetric copper(I)-catalyzed azide-alkyne cycloaddition to quaternary oxindoles

Abstract

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