Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones

Lian Peng Tong; Jing Nan Cui; Wei Min Ren; Xing Yong Wang; Xu Hong Qian

doi:10.1016/j.cclet.2008.06.037

Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones

Lian Peng Tong, Jing Nan Cui, Wei Min Ren, Xing Yong Wang, Xu Hong Qian

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity. The (+)- and (-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach (Prunus persica (L.) Batsch., conversion 98%, 71% ee) and carrot (Daucus carota L., conversion 95%, 81% ee), respectively.

Original language	English
Pages (from-to)	1179-1182
Number of pages	4
Journal	Chinese Chemical Letters
Volume	19
Issue number	10
DOIs	https://doi.org/10.1016/j.cclet.2008.06.037
State	Published - Oct 2008
Externally published	Yes

Keywords

Acenaphthenequinone
Bioreduction
Chiral hydroxyacenaphthenone
Plant enzymes

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10.1016/j.cclet.2008.06.037

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title = "Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones",

abstract = "Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity. The (+)- and (-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach (Prunus persica (L.) Batsch., conversion 98\%, 71\% ee) and carrot (Daucus carota L., conversion 95\%, 81\% ee), respectively.",

keywords = "Acenaphthenequinone, Bioreduction, Chiral hydroxyacenaphthenone, Plant enzymes",

author = "Tong, \{Lian Peng\} and Cui, \{Jing Nan\} and Ren, \{Wei Min\} and Wang, \{Xing Yong\} and Qian, \{Xu Hong\}",

year = "2008",

month = oct,

doi = "10.1016/j.cclet.2008.06.037",

language = "英语",

volume = "19",

pages = "1179--1182",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

number = "10",

}

TY - JOUR

T1 - Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems

T2 - A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones

AU - Tong, Lian Peng

AU - Cui, Jing Nan

AU - Ren, Wei Min

AU - Wang, Xing Yong

AU - Qian, Xu Hong

PY - 2008/10

Y1 - 2008/10

N2 - Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity. The (+)- and (-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach (Prunus persica (L.) Batsch., conversion 98%, 71% ee) and carrot (Daucus carota L., conversion 95%, 81% ee), respectively.

AB - Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity. The (+)- and (-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach (Prunus persica (L.) Batsch., conversion 98%, 71% ee) and carrot (Daucus carota L., conversion 95%, 81% ee), respectively.

KW - Acenaphthenequinone

KW - Bioreduction

KW - Chiral hydroxyacenaphthenone

KW - Plant enzymes

UR - https://www.scopus.com/pages/publications/52049089227

U2 - 10.1016/j.cclet.2008.06.037

DO - 10.1016/j.cclet.2008.06.037

M3 - 文章

AN - SCOPUS:52049089227

SN - 1001-8417

VL - 19

SP - 1179

EP - 1182

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 10

ER -

Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones

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Keywords

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