TY - JOUR
T1 - Associations of methylmercury and inorganic mercury between human cord blood and maternal blood
T2 - A meta-analysis and its application
AU - Ou, Langbo
AU - Chen, Long
AU - Chen, Cen
AU - Yang, Tianjun
AU - Wang, Huanghuang
AU - Tong, Yindong
AU - Hu, Dan
AU - Zhang, Wei
AU - Long, Wenjing
AU - Wang, Xuejun
PY - 2014/8
Y1 - 2014/8
N2 - Considering the different ability of placental transfer, an assessment of the cord:maternal blood ratio for both methylmercury (MeHg) and inorganic mercury (IHg) is needed especially for interpreting the low-level prenatal exposure. In this study, we conducted a Monte Carlo-based meta-analysis to comprehensively estimate that ratio for MeHg (RMeHg) and IHg (R IHg). The obtained values followed log-normal distributions, with a mean (standard deviation) of 1.89 (0.98) and 1.01 (0.55) for RMeHg and RIHg, respectively. We also estimated the percentage of MeHg in the blood by means of THg in cord and maternal blood using the RMeHg and RIHg, and obtained a value very close to the measured one (relative deviation, -0.4%). In conclusion, the fetus is exposed to approximately twice as much MeHg and to the same level of IHg as in maternal blood; the introduced model provides a rough but reasonable estimate of the percentage of MeHg in the blood.
AB - Considering the different ability of placental transfer, an assessment of the cord:maternal blood ratio for both methylmercury (MeHg) and inorganic mercury (IHg) is needed especially for interpreting the low-level prenatal exposure. In this study, we conducted a Monte Carlo-based meta-analysis to comprehensively estimate that ratio for MeHg (RMeHg) and IHg (R IHg). The obtained values followed log-normal distributions, with a mean (standard deviation) of 1.89 (0.98) and 1.01 (0.55) for RMeHg and RIHg, respectively. We also estimated the percentage of MeHg in the blood by means of THg in cord and maternal blood using the RMeHg and RIHg, and obtained a value very close to the measured one (relative deviation, -0.4%). In conclusion, the fetus is exposed to approximately twice as much MeHg and to the same level of IHg as in maternal blood; the introduced model provides a rough but reasonable estimate of the percentage of MeHg in the blood.
KW - Inorganic mercury
KW - Meta-analysis
KW - Methylmercury
KW - Monte Carlo simulation
KW - Ratio
UR - https://www.scopus.com/pages/publications/84899651352
U2 - 10.1016/j.envpol.2014.04.016
DO - 10.1016/j.envpol.2014.04.016
M3 - 文章
C2 - 24792881
AN - SCOPUS:84899651352
SN - 0269-7491
VL - 191
SP - 25
EP - 30
JO - Environmental Pollution
JF - Environmental Pollution
ER -