TY - JOUR
T1 - Association between NR4A2 genetic variation and schizophrenia
T2 - A comprehensive systematic review and meta-analysis
AU - Liu, Hongmei
AU - Fu, Yingmei
AU - Ren, Juanjuan
AU - Yu, Shunying
AU - Liu, Hongbo
AU - Jiang, Ping
AU - Dong, Yi
AU - Li, Huafang
N1 - Publisher Copyright:
© 2015 .
PY - 2015/6/6
Y1 - 2015/6/6
N2 - The homo sapiens nuclear receptor subfamily 4, group A (. NR4A2) genetic variation has been implicated as a risk factor for schizophrenia (SZ). Nevertheless, the results are inconclusive. We conducted a comprehensive systematic review and meta-analysis to quantify the impact of NR4A2 variation on the risk of SZ. All eligible case-control studies published up to September 2014 were identified by searching PubMed OVID, EBSCO, PsycINFO and ISI web of knowledge. Pooled odds ratio with 95% confidence interval were used to access the strength of association in fixed- or random-effects model. Seven studies that reported 17 variants with a total of 3027 participants were included. Of these variants, five ones (rs143618355, rs199674295, c.366-369 del TAC, c.-469delG and P4) were present only in cases, and three ones (rs35479735, rs3832066 and rs397706674) were available for meta-analysis. Overall, there was no significant association between the three variants and SZ risk under allele model, dominant model and recessive model. The results failed to reveal significant link between NR4A2 polymorphism and SZ risk. However, large-sized and well-designed studies are warranted to validate our findings.
AB - The homo sapiens nuclear receptor subfamily 4, group A (. NR4A2) genetic variation has been implicated as a risk factor for schizophrenia (SZ). Nevertheless, the results are inconclusive. We conducted a comprehensive systematic review and meta-analysis to quantify the impact of NR4A2 variation on the risk of SZ. All eligible case-control studies published up to September 2014 were identified by searching PubMed OVID, EBSCO, PsycINFO and ISI web of knowledge. Pooled odds ratio with 95% confidence interval were used to access the strength of association in fixed- or random-effects model. Seven studies that reported 17 variants with a total of 3027 participants were included. Of these variants, five ones (rs143618355, rs199674295, c.366-369 del TAC, c.-469delG and P4) were present only in cases, and three ones (rs35479735, rs3832066 and rs397706674) were available for meta-analysis. Overall, there was no significant association between the three variants and SZ risk under allele model, dominant model and recessive model. The results failed to reveal significant link between NR4A2 polymorphism and SZ risk. However, large-sized and well-designed studies are warranted to validate our findings.
KW - Meta-analysis
KW - NR4A2
KW - Schizophrenia
KW - Systematic review
UR - https://www.scopus.com/pages/publications/84930205583
U2 - 10.1016/j.neulet.2015.05.018
DO - 10.1016/j.neulet.2015.05.018
M3 - 文章
C2 - 25982322
AN - SCOPUS:84930205583
SN - 0304-3940
VL - 598
SP - 85
EP - 90
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -