Assembly of indole fluorophore in situ for hydrogen sulfide signaling through substrate triggered intramolecular reduction-cyclization cascade: A sensitive and selective probe in aqueous solution

Ji Zhou; Yuanyuan Luo; Qiang Li; Jiaoning Shen; Rui Wang; Yufang Xu; Xuhong Qian

doi:10.1039/c3nj01465g

Assembly of indole fluorophore in situ for hydrogen sulfide signaling through substrate triggered intramolecular reduction-cyclization cascade: A sensitive and selective probe in aqueous solution

Ji Zhou
, Yuanyuan Luo
, Qiang Li
, Jiaoning Shen
, Rui Wang
, Yufang Xu^*
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A novel probe containing the azide-coumarin-aldehyde triad (S1) for hydrogen sulfide (H₂S) was developed. The fluorophore for signaling is assembled in situ through a H₂S triggered intramolecular reduction-cyclization cascade, and has a concomitant 10-fold enhancement of the fluorescent intensity at 520 nm. Fluorescence imaging of H₂S in living cells proved its potential for biological application.

Original language	English
Pages (from-to)	2770-2773
Number of pages	4
Journal	New Journal of Chemistry
Volume	38
Issue number	7
DOIs	https://doi.org/10.1039/c3nj01465g
State	Published - Jul 2014
Externally published	Yes

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10.1039/c3nj01465g

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title = "Assembly of indole fluorophore in situ for hydrogen sulfide signaling through substrate triggered intramolecular reduction-cyclization cascade: A sensitive and selective probe in aqueous solution",

abstract = "A novel probe containing the azide-coumarin-aldehyde triad (S1) for hydrogen sulfide (H2S) was developed. The fluorophore for signaling is assembled in situ through a H2S triggered intramolecular reduction-cyclization cascade, and has a concomitant 10-fold enhancement of the fluorescent intensity at 520 nm. Fluorescence imaging of H2S in living cells proved its potential for biological application.",

author = "Ji Zhou and Yuanyuan Luo and Qiang Li and Jiaoning Shen and Rui Wang and Yufang Xu and Xuhong Qian",

year = "2014",

month = jul,

doi = "10.1039/c3nj01465g",

language = "英语",

volume = "38",

pages = "2770--2773",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "Royal Society of Chemistry",

number = "7",

}

Assembly of indole fluorophore in situ for hydrogen sulfide signaling through substrate triggered intramolecular reduction-cyclization cascade: A sensitive and selective probe in aqueous solution. / Zhou, Ji; Luo, Yuanyuan; Li, Qiang et al.
In: New Journal of Chemistry, Vol. 38, No. 7, 07.2014, p. 2770-2773.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Assembly of indole fluorophore in situ for hydrogen sulfide signaling through substrate triggered intramolecular reduction-cyclization cascade

T2 - A sensitive and selective probe in aqueous solution

AU - Zhou, Ji

AU - Luo, Yuanyuan

AU - Li, Qiang

AU - Shen, Jiaoning

AU - Wang, Rui

AU - Xu, Yufang

AU - Qian, Xuhong

PY - 2014/7

Y1 - 2014/7

N2 - A novel probe containing the azide-coumarin-aldehyde triad (S1) for hydrogen sulfide (H2S) was developed. The fluorophore for signaling is assembled in situ through a H2S triggered intramolecular reduction-cyclization cascade, and has a concomitant 10-fold enhancement of the fluorescent intensity at 520 nm. Fluorescence imaging of H2S in living cells proved its potential for biological application.

AB - A novel probe containing the azide-coumarin-aldehyde triad (S1) for hydrogen sulfide (H2S) was developed. The fluorophore for signaling is assembled in situ through a H2S triggered intramolecular reduction-cyclization cascade, and has a concomitant 10-fold enhancement of the fluorescent intensity at 520 nm. Fluorescence imaging of H2S in living cells proved its potential for biological application.

UR - https://www.scopus.com/pages/publications/84902665758

U2 - 10.1039/c3nj01465g

DO - 10.1039/c3nj01465g

M3 - 文章

AN - SCOPUS:84902665758

SN - 1144-0546

VL - 38

SP - 2770

EP - 2773

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 7

ER -

Assembly of indole fluorophore in situ for hydrogen sulfide signaling through substrate triggered intramolecular reduction-cyclization cascade: A sensitive and selective probe in aqueous solution

Abstract

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