Assembling Chiral Center of Heterocycles by Palladium-Catalyzed Asymmetric Hydrocarbonylation

The strategy of embedding coordinative functional group into the starting material is frequently employed to enhance reactivity and enantioselectivity in various asymmetric catalytic reactions other than enantioselective hydrocarbonylation. Recent progress in palladium- catalyzed asymmetric hydrocarbonylation with this strategy for the synthesis of chiral heterocycles was highlighted. The merits of the innate coordinative functional group not only enhance the reactivity and boost the multiple selectivity, but also facilitates the synthesis of chiral heterocycles. 1 Introduction 2 Challenges in Pd-Catalyzed Asymmetric Hydrocarbonylation 3 Pd-Catalyzed Asymmetric Hydrocarbonylation for the Synthesis of Chiral Heterocycles 4 Summary and Outlook.