Assay for uric acid level in rat striatum by a reagentless biosensor based on functionalized multi-wall carbon nanotubes with tin oxide

Fen Fen Zhang; Xiao Li Wang; Chen Xin Li; Xiao Hua Li; Qiao Wan; Yue Zhong Xian; Li Tong Jin; Katsunobu Yamamoto

doi:10.1007/s00216-005-3290-5

Assay for uric acid level in rat striatum by a reagentless biosensor based on functionalized multi-wall carbon nanotubes with tin oxide

Fen Fen Zhang, Xiao Li Wang, Chen Xin Li, Xiao Hua Li, Qiao Wan, Yue Zhong Xian, Li Tong Jin, Katsunobu Yamamoto

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A novel reagentless amperometric uric acid biosensor based on functionalized multi-wall carbon nanotubes (MWCNTs) with tin oxide (SnO ₂) nanoparticles has been developed. This was successfully applied to assay uric acid levels from an in vivo microdialysis sampling. Compared with unfunctionalized or traditional carboxylic acid (-COOH)-functionalized MWCNTs, the MWCNTs-SnO₂ electrode exhibited higher electrocatalytic oxidation to uric acid. Here, MWCNTs-SnO₂ may act as an efficient promoter, and the system exhibited a linear dependence on the uric acid concentration over the range from 1.0 × 10^-7 to 5.0 × 10^-4 mol L^-1. In addition, there was little ascorbic acid interference. The high sensitivity of the MWCNTs-SnO₂ modified enzyme electrode enabled the monitoring of trace levels of uric acid in dialysate samples in rat striatum.

Original language	English
Pages (from-to)	1368-1373
Number of pages	6
Journal	Analytical and Bioanalytical Chemistry
Volume	382
Issue number	6
DOIs	https://doi.org/10.1007/s00216-005-3290-5
State	Published - Jul 2005

Keywords

Microdialysis
Multi-wall carbon nanotubes
Tin oxide
Uric acid biosensor
Uricase

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title = "Assay for uric acid level in rat striatum by a reagentless biosensor based on functionalized multi-wall carbon nanotubes with tin oxide",

abstract = "A novel reagentless amperometric uric acid biosensor based on functionalized multi-wall carbon nanotubes (MWCNTs) with tin oxide (SnO 2) nanoparticles has been developed. This was successfully applied to assay uric acid levels from an in vivo microdialysis sampling. Compared with unfunctionalized or traditional carboxylic acid (-COOH)-functionalized MWCNTs, the MWCNTs-SnO2 electrode exhibited higher electrocatalytic oxidation to uric acid. Here, MWCNTs-SnO2 may act as an efficient promoter, and the system exhibited a linear dependence on the uric acid concentration over the range from 1.0 × 10-7 to 5.0 × 10-4 mol L-1. In addition, there was little ascorbic acid interference. The high sensitivity of the MWCNTs-SnO2 modified enzyme electrode enabled the monitoring of trace levels of uric acid in dialysate samples in rat striatum.",

keywords = "Microdialysis, Multi-wall carbon nanotubes, Tin oxide, Uric acid biosensor, Uricase",

author = "Zhang, \{Fen Fen\} and Wang, \{Xiao Li\} and Li, \{Chen Xin\} and Li, \{Xiao Hua\} and Qiao Wan and Xian, \{Yue Zhong\} and Jin, \{Li Tong\} and Katsunobu Yamamoto",

year = "2005",

month = jul,

doi = "10.1007/s00216-005-3290-5",

language = "英语",

volume = "382",

pages = "1368--1373",

journal = "Analytical and Bioanalytical Chemistry",

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T1 - Assay for uric acid level in rat striatum by a reagentless biosensor based on functionalized multi-wall carbon nanotubes with tin oxide

AU - Zhang, Fen Fen

AU - Wang, Xiao Li

AU - Li, Chen Xin

AU - Li, Xiao Hua

AU - Wan, Qiao

AU - Xian, Yue Zhong

AU - Jin, Li Tong

AU - Yamamoto, Katsunobu

PY - 2005/7

Y1 - 2005/7

N2 - A novel reagentless amperometric uric acid biosensor based on functionalized multi-wall carbon nanotubes (MWCNTs) with tin oxide (SnO 2) nanoparticles has been developed. This was successfully applied to assay uric acid levels from an in vivo microdialysis sampling. Compared with unfunctionalized or traditional carboxylic acid (-COOH)-functionalized MWCNTs, the MWCNTs-SnO2 electrode exhibited higher electrocatalytic oxidation to uric acid. Here, MWCNTs-SnO2 may act as an efficient promoter, and the system exhibited a linear dependence on the uric acid concentration over the range from 1.0 × 10-7 to 5.0 × 10-4 mol L-1. In addition, there was little ascorbic acid interference. The high sensitivity of the MWCNTs-SnO2 modified enzyme electrode enabled the monitoring of trace levels of uric acid in dialysate samples in rat striatum.

AB - A novel reagentless amperometric uric acid biosensor based on functionalized multi-wall carbon nanotubes (MWCNTs) with tin oxide (SnO 2) nanoparticles has been developed. This was successfully applied to assay uric acid levels from an in vivo microdialysis sampling. Compared with unfunctionalized or traditional carboxylic acid (-COOH)-functionalized MWCNTs, the MWCNTs-SnO2 electrode exhibited higher electrocatalytic oxidation to uric acid. Here, MWCNTs-SnO2 may act as an efficient promoter, and the system exhibited a linear dependence on the uric acid concentration over the range from 1.0 × 10-7 to 5.0 × 10-4 mol L-1. In addition, there was little ascorbic acid interference. The high sensitivity of the MWCNTs-SnO2 modified enzyme electrode enabled the monitoring of trace levels of uric acid in dialysate samples in rat striatum.

KW - Microdialysis

KW - Multi-wall carbon nanotubes

KW - Tin oxide

KW - Uric acid biosensor

KW - Uricase

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DO - 10.1007/s00216-005-3290-5

M3 - 文章

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AN - SCOPUS:23744484470

SN - 1618-2642

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SP - 1368

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JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

IS - 6

ER -

Assay for uric acid level in rat striatum by a reagentless biosensor based on functionalized multi-wall carbon nanotubes with tin oxide

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Keywords

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