Aqueous knoevenagel condensation catalyzed by aminopropyl-functionalized MCM-41

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Abstract

An efficient, environmentally friendly procedure is developed for the condensation of aldehydes/ketones and activated methylene compounds by using an aminopropyl-functionalized MCM-41 catalyst in aqueous solution. Different aldehydes/ketones and activated methylene compounds gave the corresponding alkenes in 78-97% isolated yields in mild reaction conditions. In comparison with organic solution, the aqueous solution gives higher yields in the same reaction conditions. Further more, the aminopropyl-functionalized MCM-41 in aqueous system can be reused for 8 times without significant decrease of activity.

Original languageEnglish
Pages (from-to)1293-1296
Number of pages4
JournalChinese Chemical Letters
Volume17
Issue number10
StatePublished - Oct 2006

Keywords

  • Aminopropyl-functionalized MCM41
  • Aqueous-phase reaction
  • Knoevenagel condensation

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