Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

Mengyang Zhang; Junqing He; Youbin Zheng; Guoyue Shi; Min Zhang

doi:10.1039/d2an01393b

Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

Mengyang Zhang
, Junqing He
, Youbin Zheng
, Guoyue Shi
, Min Zhang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
Technion-Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

Original language	English
Pages (from-to)	4413-4416
Number of pages	4
Journal	Analyst
Volume	147
Issue number	20
DOIs	https://doi.org/10.1039/d2an01393b
State	Published - 21 Oct 2022

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10.1039/d2an01393b

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title = "Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring",

abstract = "Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.",

author = "Mengyang Zhang and Junqing He and Youbin Zheng and Guoyue Shi and Min Zhang",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry, 2022",

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AU - Zhang, Mengyang

AU - He, Junqing

AU - Zheng, Youbin

AU - Shi, Guoyue

AU - Zhang, Min

PY - 2022/10/21

Y1 - 2022/10/21

N2 - Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

AB - Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

UR - https://www.scopus.com/pages/publications/85139572123

U2 - 10.1039/d2an01393b

DO - 10.1039/d2an01393b

M3 - 文章

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AN - SCOPUS:85139572123

SN - 0003-2654

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SP - 4413

EP - 4416

JO - Analyst

JF - Analyst

IS - 20

ER -

Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

Abstract

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