Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

Kuo Kan Liang; Michitoshi Hayashi; Ying Jen Shiu; Yan Mo; Jiushu Shao; Yijing Yan; Sheng Hsien Lin

doi:10.1002/jccs.200300050

Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

Kuo Kan Liang, Michitoshi Hayashi, Ying Jen Shiu, Yan Mo, Jiushu Shao, Yijing Yan, Sheng Hsien Lin

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.

Original language	English
Pages (from-to)	335-338
Number of pages	4
Journal	Journal of the Chinese Chemical Society
Volume	50
Issue number	3 A
DOIs	https://doi.org/10.1002/jccs.200300050
State	Published - 2003
Externally published	Yes

Keywords

Density matrix method
Generalized kinetic king model
Mean field theory
Protein folding

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10.1002/jccs.200300050

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@article{686e68e7f71a48399a03f3ddb2443833,

title = "Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding",

abstract = "The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.",

keywords = "Density matrix method, Generalized kinetic king model, Mean field theory, Protein folding",

author = "Liang, \{Kuo Kan\} and Michitoshi Hayashi and Shiu, \{Ying Jen\} and Yan Mo and Jiushu Shao and Yijing Yan and Lin, \{Sheng Hsien\}",

year = "2003",

doi = "10.1002/jccs.200300050",

language = "英语",

volume = "50",

pages = "335--338",

journal = "Journal of the Chinese Chemical Society",

issn = "0009-4536",

publisher = "John Wiley and Sons Inc",

number = "3 A",

}

TY - JOUR

T1 - Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

AU - Liang, Kuo Kan

AU - Hayashi, Michitoshi

AU - Shiu, Ying Jen

AU - Mo, Yan

AU - Shao, Jiushu

AU - Yan, Yijing

AU - Lin, Sheng Hsien

PY - 2003

Y1 - 2003

N2 - The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.

AB - The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.

KW - Density matrix method

KW - Generalized kinetic king model

KW - Mean field theory

KW - Protein folding

UR - https://www.scopus.com/pages/publications/33746075741

U2 - 10.1002/jccs.200300050

DO - 10.1002/jccs.200300050

M3 - 文章

AN - SCOPUS:33746075741

SN - 0009-4536

VL - 50

SP - 335

EP - 338

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 3 A

ER -

Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

Abstract

Keywords

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