Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

Li Lin; Xuni Cao; Wen Zhang; Yuyan Zhou; Jinhua Li; Litong Jin

Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

Li Lin, Xuni Cao, Wen Zhang, Yuyan Zhou, Jinhua Li, Litong Jin

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10^-7 mol/L to 1.0 × 10^-3 mol/L with the calculated detection limits of 1.2 × 10^-7 mol/L, 2.2 × 10^-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.

Original language	English
Pages (from-to)	261-265
Number of pages	5
Journal	Chinese Journal of Analytical Chemistry
Volume	31
Issue number	3
State	Published - 1 Mar 2003

Keywords

Chemically modified electrode
Glutathione
High performance liquid chromatography
L-cysteine
Multi-wall carbon nanotubes

Cite this

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title = "Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood",

abstract = "A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10-7 mol/L to 1.0 × 10-3 mol/L with the calculated detection limits of 1.2 × 10-7 mol/L, 2.2 × 10-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.",

keywords = "Chemically modified electrode, Glutathione, High performance liquid chromatography, L-cysteine, Multi-wall carbon nanotubes",

author = "Li Lin and Xuni Cao and Wen Zhang and Yuyan Zhou and Jinhua Li and Litong Jin",

year = "2003",

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journal = "Chinese Journal of Analytical Chemistry",

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TY - JOUR

T1 - Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

AU - Lin, Li

AU - Cao, Xuni

AU - Zhang, Wen

AU - Zhou, Yuyan

AU - Li, Jinhua

AU - Jin, Litong

PY - 2003/3/1

Y1 - 2003/3/1

N2 - A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10-7 mol/L to 1.0 × 10-3 mol/L with the calculated detection limits of 1.2 × 10-7 mol/L, 2.2 × 10-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.

AB - A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10-7 mol/L to 1.0 × 10-3 mol/L with the calculated detection limits of 1.2 × 10-7 mol/L, 2.2 × 10-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.

KW - Chemically modified electrode

KW - Glutathione

KW - High performance liquid chromatography

KW - L-cysteine

KW - Multi-wall carbon nanotubes

UR - https://www.scopus.com/pages/publications/0038755000

M3 - 文章

AN - SCOPUS:0038755000

SN - 0253-3820

VL - 31

SP - 261

EP - 265

JO - Chinese Journal of Analytical Chemistry

JF - Chinese Journal of Analytical Chemistry

IS - 3

ER -

Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

Abstract

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