Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

Li Lin; Xuni Cao; Wen Zhang; Yuyan Zhou; Jinhua Li; Litong Jin

Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

Li Lin
, Xuni Cao
, Wen Zhang
, Yuyan Zhou
, Jinhua Li
, Litong Jin^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10^-7 mol/L to 1.0 × 10^-3 mol/L with the calculated detection limits of 1.2 × 10^-7 mol/L, 2.2 × 10^-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.

Original language	English
Pages (from-to)	261-265
Number of pages	5
Journal	Chinese Journal of Analytical Chemistry
Volume	31
Issue number	3
State	Published - 1 Mar 2003

Keywords

Chemically modified electrode
Glutathione
High performance liquid chromatography
L-cysteine
Multi-wall carbon nanotubes

Cite this

@article{535e4550bbde41c995822c565c0248e0,

title = "Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood",

abstract = "A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10-7 mol/L to 1.0 × 10-3 mol/L with the calculated detection limits of 1.2 × 10-7 mol/L, 2.2 × 10-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.",

keywords = "Chemically modified electrode, Glutathione, High performance liquid chromatography, L-cysteine, Multi-wall carbon nanotubes",

author = "Li Lin and Xuni Cao and Wen Zhang and Yuyan Zhou and Jinhua Li and Litong Jin",

year = "2003",

month = mar,

day = "1",

language = "英语",

volume = "31",

pages = "261--265",

journal = "Chinese Journal of Analytical Chemistry",

issn = "0253-3820",

publisher = "Chinese Academy of Sciences",

number = "3",

}

TY - JOUR

T1 - Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

AU - Lin, Li

AU - Cao, Xuni

AU - Zhang, Wen

AU - Zhou, Yuyan

AU - Li, Jinhua

AU - Jin, Litong

PY - 2003/3/1

Y1 - 2003/3/1

N2 - A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10-7 mol/L to 1.0 × 10-3 mol/L with the calculated detection limits of 1.2 × 10-7 mol/L, 2.2 × 10-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.

AB - A new chemically modified electrode(CME) was fabricated based on the immobilization of multi-wall carbon nanotubes fuctionalized with carboxylic group. The results indicated that the CME exhibited efficiently electrocatalytic oxidation for L-cysteine and glutathione with relatively high sensitivity, stability and long-life. Coupled with high performance liquid chromatography, the CME is utilized for electrochemical detection of thiols. The peak currents of L-cysteine and glutathione were linear to their concentrations ranged from 3.0 × 10-7 mol/L to 1.0 × 10-3 mol/L with the calculated detection limits of 1.2 × 10-7 mol/L, 2.2 × 10-7 mol/L, respectively. The method had been successfully applied to assess the contents of L-cysteine and glutathione in human whole blood.

KW - Chemically modified electrode

KW - Glutathione

KW - High performance liquid chromatography

KW - L-cysteine

KW - Multi-wall carbon nanotubes

UR - https://www.scopus.com/pages/publications/0038755000

M3 - 文章

AN - SCOPUS:0038755000

SN - 0253-3820

VL - 31

SP - 261

EP - 265

JO - Chinese Journal of Analytical Chemistry

JF - Chinese Journal of Analytical Chemistry

IS - 3

ER -

Application for multiwall carbon nanotubes modified electrode to liquid chromatography for determination of the thiols in human whole blood

Abstract

Keywords

Other files and links

Fingerprint

Cite this