Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering

Tian Fu Li; Yi Yun Cheng; Yu Wang; Hui Wang; Dong Feng Chen; Yun Tao Liu; Li Zhang; Wen Ze Han; Rong Deng Liu; Zi Jun Wang; Chun Ming Yang; Charl J. Jafta; Daniel Clemens; Uwe Keiderling

doi:10.1007/s10118-019-2260-x

Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering

Tian Fu Li^*
, Yi Yun Cheng
, Yu Wang
, Hui Wang
, Dong Feng Chen
, Yun Tao Liu
, Li Zhang
, Wen Ze Han
, Rong Deng Liu
, Zi Jun Wang
, Chun Ming Yang
, Charl J. Jafta
, Daniel Clemens
, Uwe Keiderling

^*Corresponding author for this work

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Dimer impurity in the solution of a generation five (G5) polyamidoamine (PAMAM) dendrimer has been investigated by small-angle neutron scattering (SANS). The existence of dimer impurity in dendrimer solution was evidenced by indirect Fourier transform (IFT) analysis of the SANS data, in which the maximum dimension of particles in solution was found to be about twice the diameter of G5 dendrimer. We then developed an analytical model which accounts for the scattering contribution from both dendrimer monomer and dimer. The experimental data were well fitted by using the established model. The results showed that the amount of dimer impurities is significant for the measured three batches of G5 PAMAM dendrimers.

Original language	English
Pages (from-to)	827-833
Number of pages	7
Journal	Chinese Journal of Polymer Science (English Edition)
Volume	37
Issue number	8
DOIs	https://doi.org/10.1007/s10118-019-2260-x
State	Published - 1 Aug 2019

Keywords

Dimer impurity
PAMAM dendrimer
Scattering model
Small-angle neutron scattering

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10.1007/s10118-019-2260-x

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Li, T. F., Cheng, Y. Y., Wang, Y., Wang, H., Chen, D. F., Liu, Y. T., Zhang, L., Han, W. Z., Liu, R. D., Wang, Z. J., Yang, C. M., Jafta, C. J., Clemens, D., & Keiderling, U. (2019). Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering. Chinese Journal of Polymer Science (English Edition), 37(8), 827-833. https://doi.org/10.1007/s10118-019-2260-x

@article{e2866d58b15446dab7f469c880436144,

title = "Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering",

abstract = "Dimer impurity in the solution of a generation five (G5) polyamidoamine (PAMAM) dendrimer has been investigated by small-angle neutron scattering (SANS). The existence of dimer impurity in dendrimer solution was evidenced by indirect Fourier transform (IFT) analysis of the SANS data, in which the maximum dimension of particles in solution was found to be about twice the diameter of G5 dendrimer. We then developed an analytical model which accounts for the scattering contribution from both dendrimer monomer and dimer. The experimental data were well fitted by using the established model. The results showed that the amount of dimer impurities is significant for the measured three batches of G5 PAMAM dendrimers.",

keywords = "Dimer impurity, PAMAM dendrimer, Scattering model, Small-angle neutron scattering",

author = "Li, \{Tian Fu\} and Cheng, \{Yi Yun\} and Yu Wang and Hui Wang and Chen, \{Dong Feng\} and Liu, \{Yun Tao\} and Li Zhang and Han, \{Wen Ze\} and Liu, \{Rong Deng\} and Wang, \{Zi Jun\} and Yang, \{Chun Ming\} and Jafta, \{Charl J.\} and Daniel Clemens and Uwe Keiderling",

note = "Publisher Copyright: {\textcopyright} 2019, Chinese Chemical Society Institute of Chemistry, Chinese Academy of Sciences Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2019",

month = aug,

day = "1",

doi = "10.1007/s10118-019-2260-x",

language = "英语",

volume = "37",

pages = "827--833",

journal = "Chinese Journal of Polymer Science (English Edition)",

issn = "0256-7679",

publisher = "Springer Verlag",

number = "8",

}

Li, TF, Cheng, YY, Wang, Y, Wang, H, Chen, DF, Liu, YT, Zhang, L, Han, WZ, Liu, RD, Wang, ZJ, Yang, CM, Jafta, CJ, Clemens, D & Keiderling, U 2019, 'Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering', Chinese Journal of Polymer Science (English Edition), vol. 37, no. 8, pp. 827-833. https://doi.org/10.1007/s10118-019-2260-x

TY - JOUR

T1 - Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering

AU - Li, Tian Fu

AU - Cheng, Yi Yun

AU - Wang, Yu

AU - Wang, Hui

AU - Chen, Dong Feng

AU - Liu, Yun Tao

AU - Zhang, Li

AU - Han, Wen Ze

AU - Liu, Rong Deng

AU - Wang, Zi Jun

AU - Yang, Chun Ming

AU - Jafta, Charl J.

AU - Clemens, Daniel

AU - Keiderling, Uwe

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Dimer impurity in the solution of a generation five (G5) polyamidoamine (PAMAM) dendrimer has been investigated by small-angle neutron scattering (SANS). The existence of dimer impurity in dendrimer solution was evidenced by indirect Fourier transform (IFT) analysis of the SANS data, in which the maximum dimension of particles in solution was found to be about twice the diameter of G5 dendrimer. We then developed an analytical model which accounts for the scattering contribution from both dendrimer monomer and dimer. The experimental data were well fitted by using the established model. The results showed that the amount of dimer impurities is significant for the measured three batches of G5 PAMAM dendrimers.

AB - Dimer impurity in the solution of a generation five (G5) polyamidoamine (PAMAM) dendrimer has been investigated by small-angle neutron scattering (SANS). The existence of dimer impurity in dendrimer solution was evidenced by indirect Fourier transform (IFT) analysis of the SANS data, in which the maximum dimension of particles in solution was found to be about twice the diameter of G5 dendrimer. We then developed an analytical model which accounts for the scattering contribution from both dendrimer monomer and dimer. The experimental data were well fitted by using the established model. The results showed that the amount of dimer impurities is significant for the measured three batches of G5 PAMAM dendrimers.

KW - Dimer impurity

KW - PAMAM dendrimer

KW - Scattering model

KW - Small-angle neutron scattering

UR - https://www.scopus.com/pages/publications/85065190966

U2 - 10.1007/s10118-019-2260-x

DO - 10.1007/s10118-019-2260-x

M3 - 文章

AN - SCOPUS:85065190966

SN - 0256-7679

VL - 37

SP - 827

EP - 833

JO - Chinese Journal of Polymer Science (English Edition)

JF - Chinese Journal of Polymer Science (English Edition)

IS - 8

ER -

Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering

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