An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB

Qingwen He; Lili Wu; Zepeng Xu; Xiaoyun Wang; Yufeng Xie; Yan Chai; Anqi Zheng; Jianjie Zhou; Shitong Qiao; Min Huang; Guijun Shang; Xin Zhao; Youjun Feng; Jianxun Qi; George Fu Gao; Qihui Wang

doi:10.1016/j.xcrm.2023.100991

An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB

Qingwen He
, Lili Wu
, Zepeng Xu
, Xiaoyun Wang
, Yufeng Xie
, Yan Chai
, Anqi Zheng
, Jianjie Zhou
, Shitong Qiao
, Min Huang
, Guijun Shang
, Xin Zhao
, Youjun Feng
, Jianxun Qi^*
, George Fu Gao^*
, Qihui Wang^*

^*Corresponding author for this work

Zhejiang University
CAS - Institute of Microbiology
University of Chinese Academy of Sciences
Tsinghua University
University of Science and Technology of China
Shanxi Academy of Advanced Research and Innovation
Chinese Center for Disease Control and Prevention

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Emerging Omicron sub-variants are causing global concerns, and their immune evasion should be monitored continuously. We previously evaluated the escape of Omicron BA.1, BA.1.1, BA.2, and BA.3 from an atlas of 50 monoclonal antibodies (mAbs), covering seven epitope classes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD). Here, we update the atlas of totally 77 mAbs against emerging sub-variants including BQ.1.1 and XBB and find that BA.4/5, BQ.1.1, and XBB display further evasion. Besides, investigation into the correlation of binding and neutralization of mAbs reveals the important role of antigenic conformation in mAb functioning. Moreover, the complex structures of BA.2 RBD/BD-604/S304 and BA.4/5 RBD/BD-604/S304/S309 further elucidate the molecular mechanism of antibody evasion by these sub-variants. By focusing on the identified broadly potent mAbs, we find a general hotspot epitope on the RBD, which could guide the design of vaccines and calls for new broad-spectrum countermeasures against COVID-19.

Original language	English
Article number	100991
Journal	Cell Reports Medicine
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/j.xcrm.2023.100991
State	Published - 18 Apr 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BA.2.13
BA.2.75
BA.4
BA.5
BQ.1.1
Omicron BA.2.12.1
SARS-CoV-2
XBB
human neutralizing antibodies
immune escape

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10.1016/j.xcrm.2023.100991

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title = "An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB",

abstract = "Emerging Omicron sub-variants are causing global concerns, and their immune evasion should be monitored continuously. We previously evaluated the escape of Omicron BA.1, BA.1.1, BA.2, and BA.3 from an atlas of 50 monoclonal antibodies (mAbs), covering seven epitope classes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD). Here, we update the atlas of totally 77 mAbs against emerging sub-variants including BQ.1.1 and XBB and find that BA.4/5, BQ.1.1, and XBB display further evasion. Besides, investigation into the correlation of binding and neutralization of mAbs reveals the important role of antigenic conformation in mAb functioning. Moreover, the complex structures of BA.2 RBD/BD-604/S304 and BA.4/5 RBD/BD-604/S304/S309 further elucidate the molecular mechanism of antibody evasion by these sub-variants. By focusing on the identified broadly potent mAbs, we find a general hotspot epitope on the RBD, which could guide the design of vaccines and calls for new broad-spectrum countermeasures against COVID-19.",

keywords = "BA.2.13, BA.2.75, BA.4, BA.5, BQ.1.1, Omicron BA.2.12.1, SARS-CoV-2, XBB, human neutralizing antibodies, immune escape",

author = "Qingwen He and Lili Wu and Zepeng Xu and Xiaoyun Wang and Yufeng Xie and Yan Chai and Anqi Zheng and Jianjie Zhou and Shitong Qiao and Min Huang and Guijun Shang and Xin Zhao and Youjun Feng and Jianxun Qi and Gao, \{George Fu\} and Qihui Wang",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

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day = "18",

doi = "10.1016/j.xcrm.2023.100991",

language = "英语",

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journal = "Cell Reports Medicine",

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T1 - An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB

AU - He, Qingwen

AU - Wu, Lili

AU - Xu, Zepeng

AU - Wang, Xiaoyun

AU - Xie, Yufeng

AU - Chai, Yan

AU - Zheng, Anqi

AU - Zhou, Jianjie

AU - Qiao, Shitong

AU - Huang, Min

AU - Shang, Guijun

AU - Zhao, Xin

AU - Feng, Youjun

AU - Qi, Jianxun

AU - Gao, George Fu

AU - Wang, Qihui

PY - 2023/4/18

Y1 - 2023/4/18

N2 - Emerging Omicron sub-variants are causing global concerns, and their immune evasion should be monitored continuously. We previously evaluated the escape of Omicron BA.1, BA.1.1, BA.2, and BA.3 from an atlas of 50 monoclonal antibodies (mAbs), covering seven epitope classes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD). Here, we update the atlas of totally 77 mAbs against emerging sub-variants including BQ.1.1 and XBB and find that BA.4/5, BQ.1.1, and XBB display further evasion. Besides, investigation into the correlation of binding and neutralization of mAbs reveals the important role of antigenic conformation in mAb functioning. Moreover, the complex structures of BA.2 RBD/BD-604/S304 and BA.4/5 RBD/BD-604/S304/S309 further elucidate the molecular mechanism of antibody evasion by these sub-variants. By focusing on the identified broadly potent mAbs, we find a general hotspot epitope on the RBD, which could guide the design of vaccines and calls for new broad-spectrum countermeasures against COVID-19.

AB - Emerging Omicron sub-variants are causing global concerns, and their immune evasion should be monitored continuously. We previously evaluated the escape of Omicron BA.1, BA.1.1, BA.2, and BA.3 from an atlas of 50 monoclonal antibodies (mAbs), covering seven epitope classes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD). Here, we update the atlas of totally 77 mAbs against emerging sub-variants including BQ.1.1 and XBB and find that BA.4/5, BQ.1.1, and XBB display further evasion. Besides, investigation into the correlation of binding and neutralization of mAbs reveals the important role of antigenic conformation in mAb functioning. Moreover, the complex structures of BA.2 RBD/BD-604/S304 and BA.4/5 RBD/BD-604/S304/S309 further elucidate the molecular mechanism of antibody evasion by these sub-variants. By focusing on the identified broadly potent mAbs, we find a general hotspot epitope on the RBD, which could guide the design of vaccines and calls for new broad-spectrum countermeasures against COVID-19.

KW - BA.2.13

KW - BA.2.75

KW - BA.4

KW - BA.5

KW - BQ.1.1

KW - Omicron BA.2.12.1

KW - SARS-CoV-2

KW - XBB

KW - human neutralizing antibodies

KW - immune escape

UR - https://www.scopus.com/pages/publications/85151497273

U2 - 10.1016/j.xcrm.2023.100991

DO - 10.1016/j.xcrm.2023.100991

M3 - 文章

C2 - 37019110

AN - SCOPUS:85151497273

SN - 2666-3791

VL - 4

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 4

M1 - 100991

ER -

An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB

Abstract

UN SDGs

Keywords

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