Abstract
We report an organocatalytic addition of nitromethane to aryl α-ketoester-derived N-tosyl ketimines or isatin-derived N-tert-butyloxycarbonyl ketimines, catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (1-5mol%). Initial screenings reveal that the reaction with a quinine-derived bifunctional catalyst, which features a C6 phenolic hydroxy group, achieved up to 71% ee.
| Original language | English |
|---|---|
| Pages (from-to) | 429-432 |
| Number of pages | 4 |
| Journal | Asian Journal of Organic Chemistry |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2014 |
Keywords
- Amino acids
- Aminoxoindoles
- Aza-Henry reaction
- Isatins
- Ketimines