An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

Hui Li; Jinlong Yu; Song Cao; Li Shen; Mingxi Wu; Jianhang Cheng; Xuhong Qian

doi:10.1007/s11426-010-4005-0

An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

Hui Li
, Jinlong Yu
, Song Cao^*
, Li Shen
, Mingxi Wu
, Jianhang Cheng
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA), a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free conditions. The comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate, ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.

Original language	English
Pages (from-to)	1509-1513
Number of pages	5
Journal	Science China Chemistry
Volume	53
Issue number	7
DOIs	https://doi.org/10.1007/s11426-010-4005-0
State	Published - Jul 2010
Externally published	Yes

Keywords

1-4-dihydropyridines
difluoromethyl
ethyl difluoroacetoacetate
three-component

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10.1007/s11426-010-4005-0

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title = "An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions",

abstract = "The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA), a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free conditions. The comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate, ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.",

keywords = "1-4-dihydropyridines, difluoromethyl, ethyl difluoroacetoacetate, three-component",

author = "Hui Li and Jinlong Yu and Song Cao and Li Shen and Mingxi Wu and Jianhang Cheng and Xuhong Qian",

year = "2010",

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doi = "10.1007/s11426-010-4005-0",

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TY - JOUR

T1 - An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

AU - Li, Hui

AU - Yu, Jinlong

AU - Cao, Song

AU - Shen, Li

AU - Wu, Mingxi

AU - Cheng, Jianhang

AU - Qian, Xuhong

PY - 2010/7

Y1 - 2010/7

N2 - The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA), a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free conditions. The comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate, ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.

AB - The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA), a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free conditions. The comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate, ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.

KW - 1-4-dihydropyridines

KW - difluoromethyl

KW - ethyl difluoroacetoacetate

KW - three-component

UR - https://www.scopus.com/pages/publications/77955526583

U2 - 10.1007/s11426-010-4005-0

DO - 10.1007/s11426-010-4005-0

M3 - 文章

AN - SCOPUS:77955526583

SN - 1674-7291

VL - 53

SP - 1509

EP - 1513

JO - Science China Chemistry

JF - Science China Chemistry

IS - 7

ER -

An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

Abstract

Keywords

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