An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin

Fu Min Liao; Yun Lin Liu; Jin Sheng Yu; Feng Zhou; Jian Zhou

doi:10.1039/c5ob01125f

An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin

Fu Min Liao
, Yun Lin Liu
, Jin Sheng Yu
, Feng Zhou
, Jian Zhou^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.

Original language	English
Pages (from-to)	8906-8911
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	33
DOIs	https://doi.org/10.1039/c5ob01125f
State	Published - 15 Jul 2015

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title = "An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin",

abstract = "We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.",

author = "Liao, \{Fu Min\} and Liu, \{Yun Lin\} and Yu, \{Jin Sheng\} and Feng Zhou and Jian Zhou",

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doi = "10.1039/c5ob01125f",

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T1 - An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin

AU - Liao, Fu Min

AU - Liu, Yun Lin

AU - Yu, Jin Sheng

AU - Zhou, Feng

AU - Zhou, Jian

PY - 2015/7/15

Y1 - 2015/7/15

N2 - We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.

AB - We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.

UR - https://www.scopus.com/pages/publications/84938933965

U2 - 10.1039/c5ob01125f

DO - 10.1039/c5ob01125f

M3 - 文章

C2 - 26205007

AN - SCOPUS:84938933965

SN - 1477-0520

VL - 13

SP - 8906

EP - 8911

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 33

ER -

An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin

Abstract

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