An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

Meihua Yu; Yuting Niu; Yannan Yang; Sandy Budi Hartono; Jie Yang; Xiaodan Huang; Peter Thorn; Chengzhong Yu

doi:10.1021/am503060n

An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

Meihua Yu
, Yuting Niu
, Yannan Yang
, Sandy Budi Hartono
, Jie Yang
, Xiaodan Huang
, Peter Thorn
, Chengzhong Yu^*

^*Corresponding author for this work

University of Queensland

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.

Original language	English
Pages (from-to)	15626-15631
Number of pages	6
Journal	ACS Applied Materials and Interfaces
Volume	6
Issue number	18
DOIs	https://doi.org/10.1021/am503060n
State	Published - 24 Sep 2014
Externally published	Yes

Keywords

Gene delivery
Polyethylenimine
SiRNA
Silica nanoparticles
Surface modification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/am503060n

Cite this

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title = "An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery",

abstract = "A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.",

keywords = "Gene delivery, Polyethylenimine, SiRNA, Silica nanoparticles, Surface modification",

author = "Meihua Yu and Yuting Niu and Yannan Yang and Hartono, \{Sandy Budi\} and Jie Yang and Xiaodan Huang and Peter Thorn and Chengzhong Yu",

note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",

year = "2014",

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doi = "10.1021/am503060n",

language = "英语",

volume = "6",

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T1 - An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

AU - Yu, Meihua

AU - Niu, Yuting

AU - Yang, Yannan

AU - Hartono, Sandy Budi

AU - Yang, Jie

AU - Huang, Xiaodan

AU - Thorn, Peter

AU - Yu, Chengzhong

PY - 2014/9/24

Y1 - 2014/9/24

N2 - A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.

AB - A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.

KW - Gene delivery

KW - Polyethylenimine

KW - SiRNA

KW - Silica nanoparticles

KW - Surface modification

UR - https://www.scopus.com/pages/publications/84912048749

U2 - 10.1021/am503060n

DO - 10.1021/am503060n

M3 - 文章

C2 - 25184370

AN - SCOPUS:84912048749

SN - 1944-8244

VL - 6

SP - 15626

EP - 15631

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 18

ER -

An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

Abstract

Keywords

UN SDGs

Access to Document

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