An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice

Yijing Dang; Fengyang Wang; Lingling Li; Yi Lai; Zhiai Xu; Zhi Xiong; Ao Zhang; Yang Tian; Chunyong Ding; Wen Zhang

doi:10.1039/c9cc08265d

An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice

Yijing Dang
, Fengyang Wang
, Lingling Li
, Yi Lai
, Zhiai Xu^*
, Zhi Xiong
, Ao Zhang
, Yang Tian
, Chunyong Ding
, Wen Zhang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
CAS - Shanghai Institute of Materia Medica

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, we disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by utilizing a thiadiazole-fused o-phenylenediamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis.

Original language	English
Pages (from-to)	707-710
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	5
DOIs	https://doi.org/10.1039/c9cc08265d
State	Published - 2020

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title = "An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice",

abstract = "Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, we disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by utilizing a thiadiazole-fused o-phenylenediamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis.",

author = "Yijing Dang and Fengyang Wang and Lingling Li and Yi Lai and Zhiai Xu and Zhi Xiong and Ao Zhang and Yang Tian and Chunyong Ding and Wen Zhang",

note = "Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",

year = "2020",

doi = "10.1039/c9cc08265d",

language = "英语",

volume = "56",

pages = "707--710",

journal = "Chemical Communications",

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TY - JOUR

T1 - An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice

AU - Dang, Yijing

AU - Wang, Fengyang

AU - Li, Lingling

AU - Lai, Yi

AU - Xu, Zhiai

AU - Xiong, Zhi

AU - Zhang, Ao

AU - Tian, Yang

AU - Ding, Chunyong

AU - Zhang, Wen

PY - 2020

Y1 - 2020

N2 - Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, we disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by utilizing a thiadiazole-fused o-phenylenediamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis.

AB - Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, we disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by utilizing a thiadiazole-fused o-phenylenediamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis.

UR - https://www.scopus.com/pages/publications/85077948355

U2 - 10.1039/c9cc08265d

DO - 10.1039/c9cc08265d

M3 - 文章

C2 - 31850402

AN - SCOPUS:85077948355

SN - 1359-7345

VL - 56

SP - 707

EP - 710

JO - Chemical Communications

JF - Chemical Communications

IS - 5

ER -

An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice

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